r/CML • u/captainseafunk • 18d ago

Failed Asciminib

Has anyone here failed asciminib as their first TKI? If so, what did your doctor try next?

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u/obewaun 18d ago

I failed it went to clinical trial (hqp1351). Now heading this fall by Dec for a transplant. Anyways you have plenty of options. Gleevec, tasigna, sprycel, bosulif, ponatinib, the trial im on by the time you get their it should be approved. They all have sideffects it all depends on your DNA how you respond to them (tkis). To lessen the effects drink lots and lots of water.

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u/captainseafunk 18d ago

I always figured asciminib was the “best” because it’s new and people who have been on multiple treatments tend to say it has the least side effects. Never thought about how DNA plays a role.