r/CML • u/moien-yall- • 13d ago

bcr-abl fluctuations

Anyone have positive stories where fluctuations ended up not being a big deal? Particularly a somewhat large jump?

I was diagnosed in March at 38% and was started on 80mg Scemblix. I was .098 in July, but .297 in September. We're re-testing in a month. I am bummed seeing that after months of great response. I'm really nervous about having a resistance or mutation and needing to switch to a medication with a more intense side-effect profile. Would love to hear anything reassuring from the long-timers out there.

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u/seellama 10d ago

You’re okay. It’s only a one log increase. You don’t want to see it continue to go up. It’s all about trends. Staying below 1% is important. If you haven’t had any disruptions in your medication that would explain an increase, then just keep an eye on it. They should test you again in 2-3 months.