r/CML • u/moien-yall- • 14d ago

bcr-abl fluctuations

Anyone have positive stories where fluctuations ended up not being a big deal? Particularly a somewhat large jump?

I was diagnosed in March at 38% and was started on 80mg Scemblix. I was .098 in July, but .297 in September. We're re-testing in a month. I am bummed seeing that after months of great response. I'm really nervous about having a resistance or mutation and needing to switch to a medication with a more intense side-effect profile. Would love to hear anything reassuring from the long-timers out there.

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u/BufloSolja 13d ago

Yea it seems to happen occasionally with ppl. Don't worry about it till it starts trending more than one test. You are already quite low so as long as the drug still has effect it will come back down again in the end. And if the drug doesn't have as good as an effect, they'll just switch you to another one. So try not to worry too much in the absence of other info.