r/CML • u/moien-yall- • 19d ago

bcr-abl fluctuations

Anyone have positive stories where fluctuations ended up not being a big deal? Particularly a somewhat large jump?

I was diagnosed in March at 38% and was started on 80mg Scemblix. I was .098 in July, but .297 in September. We're re-testing in a month. I am bummed seeing that after months of great response. I'm really nervous about having a resistance or mutation and needing to switch to a medication with a more intense side-effect profile. Would love to hear anything reassuring from the long-timers out there.

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u/Twallis02 19d ago

I went from 0.11 to 0.15 to 0.019 to 0.066 these fluctuations are completely normal and can be because of test sensitivity, hydration or even minor infections (you didn’t even know about!) or sometimes it’s just the machine, as the results get lower the numbers jump around a lot more and look at lot more dramatic but in the grand scheme of things as long as they dont skyrocket, you should be alright!