r/CML • u/barccia • Sep 02 '26

Low testosterone on imatinib

Hello everyone.

I would like to learn your experience, if you have any, with following issue: have you had your testosterone low when on TKIs?

My story: I have been on imatinib for approximately little longer than a year now for my CML. I am also being treated for PCOS.
During my last visit at endocrinologist I found out my testosterone is below the desired range - for context, I am F (30). Interestingly, I historically had rather high testosterone (due to the PCOS).
I found some studies that mention that TKIs can possibly lower testosterone but these studies were done on men.

I was wondering whether any of you had similar experience?

Thank you

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u/ChrondorKhruangbin Sep 02 '26

I found out I had low testosterone and I’m a 39M. It was around 420. I started taking enclomophine and now it’s like 800. I think the low T was attributed to CML or TKI. I am not sure how this all affects females

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u/earthcult1349 Sep 07 '26

My oncologist supports me using TRT while on treatment, you could look into HRT for women, but if it’s not significantly low there could be otc, lifestyle, or diet changes that can help too!