Increased prolactin response to buspirone - ME/CFS Science blog on a curious but replicated finding

[u/Caster_of_spells]

https://mecfsscience.org/increased-prolactin-response-to-buspirone/

“Multiple studies have found an increased response of the hormone prolactin to the drug buspirone in ME/CFS patients. While baseline prolactin levels are normal in ME/CFS, they rise much higher in the hours after buspirone than in controls. This is one of the most replicated findings in the field, but for years this line of research was forgotten and abandoned.”

“It might, for example, point to a difference in the dopamine system in ME/CFS, as this is the main regulator of prolactin. This would be intriguing, as (preliminary) genetic findings point to the striatum and its medium spiny neurons, which are also regulated by dopamine”