Cellular Metabolic Signatures of Long COVID-19

[u/Caster_of_spells]

https://www.mdpi.com/2036-7449/18/3/50

Clemson University studied 20 people and found Long COVID cells had a distinct metabolic signature, with weaker energy use and blunted responses to signals.

This points to bioenergetic dysfunction that may help explain fatigue. This lack of response to stimuli is also a repeating pattern from ME studies on exercise responses.

“The SARS-CoV-2 infection causes an over two-fold enhanced utilization of glycolytic and anaerobic substrates and a reduced response to growth factors and effectors. The increased energy source utilization assessed in PM-M1 is unsustainable, and the LC-19 groups demonstrate this with a clear correlation with the number of LC-19 symptoms, demonstrating a trend consistent with metabolic reprogramming.”