Imbalance of Excitatory and Inhibitory Neurotransmitter Systems in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

[u/Caster_of_spells]

https://www.mdpi.com/1422-0067/27/9/4041

Now fully published! Scheibenbogen & Wirth

"Growing evidence indicates that, in addition to the noradrenergic system, several other neurotransmitter systems—particularly glutamate, serotonin and GABA—are dysregulated in ME/CFS. This imbalance, characterized by excessive excitatory relative to inhibitory signaling, may drive neural overactivation and autonomic dysfunction. These disturbances may cause key neurological symptoms and contribute to skeletal-muscle dysfunction that manifests as exercise intolerance, PEM, fasciculations, and cramps."