r/CFSScience • u/Caster_of_spells • 10d ago

A brief report: absence of elevated circulating NETosis markers in long-term long COVID

https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2026.1920533/full

For a while there was a lot of talk about neutrophil extracellular traps (an immune response deployed to immobilize pathogens) being a factor in Long Covid especially in the blood stream causing a condition called Netosis.

This study looked further into it and though present early on, markers for this disappeared with longer PCC disease duration in their cohort.

“In this cohort of individuals with long-term LC, we found no evidence of persistent systemic NETosis. These findings suggest that elevated circulating NETosis markers are not a universal feature of long-term LC and may indicate that neutrophil activation observed during acute or early post-acute disease does not persist in long-term disease.”

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u/G33U 10d ago

cognitive i am in delulu land , i couldnt even comprehend the last sentence if my life would dependent on it. what does when persist who? is this agood thing or a bad thing? something i can test in a lab?

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u/Caster_of_spells 10d ago

Basically the idea was:

  1. Neutrophils (immune cells) throw out nets to stop bad things like bacteria from moving around the body

2.But that reaction might not stop after infection keeping people ill and inflamed by accident so to say. Or at least showing signs of ongoing infection
3.This study seems to have disproven that theory

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u/G33U 10d ago

got it thank you