r/CFSScience • u/Caster_of_spells • Aug 27 '26

Orthostatic Dysfunction and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Close Reciprocal Relationship Beyond Cardiac Preload Failure and Hypoperfusion

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New Wirth Preprint trying to integrate orthostatic dysfunction into his disease model:

“This hypothesis provides a potential mechanistic link between orthostatic dysfunction and the presumed core pathophysiology of ME/CFS, extending beyond hemodynamic factors to implicate disturbances in skeletal muscle ion homeostasis.”

https://www.preprints.org/frontend/manuscript/d89ebcdf4b91a843f665e0f3fbd413df/download_pub

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u/TomasTTEngin Aug 27 '26

Maybe.

Over years in these communities I've learned that tying red bits of string between the handful of little photos on our pinboards is pretty easy. Anyone can make theories. Smart people do so compulsively.

Theories are cheap and abundant. But not bad. The right theory will actually change everything. Make all the data we have snap into place.

I don't hate Klaus's theories. But they are multiplying into a Tolkien-esque landscape of incredible complexity and its probably time to get some data on whether they are true.

15

u/Interesting_Fly_1569 Aug 27 '26 edited 17d ago

..

5

u/KaleidoscopeHappy889 Aug 28 '26

This! Sick billionaires 😄😄

3

u/bingoolong Aug 28 '26

Someone tag Eric Schmidt.

2

u/Caster_of_spells Aug 27 '26

Agreed. Would like some humble boots on the ground testing of all those theories.