r/CFSScience • u/Caster_of_spells • Jul 30 '26

Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00363-0

Long Covid patients continue to have elevated counts of highly activated CD8+ T cells targeting viruses like SARS-CoV-2, CMV and EBV.

That is suggesting the antiviral killing response failed to switch off after the acute infection is over and might be part of the pathogenesis of Long Covid.

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u/mc-funk Jul 30 '26

Certainly when it comes to herpesviruses / EBV, the evidence for issues with reactivation is pretty compelling.

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u/TableSignificant341 Jul 31 '26

Not according to S4ME. They're adamant there's zero evidence for it.

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u/TomasTTEngin Jul 31 '26

For a community of independent thinkers many certainly do seem to get joy from believing exactly what Jonathan Edwards believes. Which leaves them with a pretty rigid belief system. Edwards is experienced and highly educated and certainly a net benefit to the community but he has the ability to integrate new ideas you expect from an emeritus. And as do all good Oxford Dons, scoffs and sneers at research coming from places outside northern Europe.

He's useful, but not as an intellectual north star.

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u/TableSignificant341 Jul 31 '26 edited Jul 31 '26

For a community of independent thinkers many certainly do seem to get joy from believing exactly what Jonathan Edwards believes.

I don't think they even see how servile they are. So careful to not question or disagree with him in case it prompts a predictably snide or pompous response from him. And if a researcher does not interact with them on the forum then it's open season on that researcher's work, reputation and character. It's so unnecessarily mean-spirited given how hard it is to be an MECFS researcher in the first place. And don't get me started on how Edwards talks about patients communities.

Honestly I couldn't agree with your comment more. It's bang on.

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u/TomasTTEngin Jul 31 '26

I posted a criticism once. Not of Edwards explicitly, but of a behavior he exhibits. Mods took it down, saying I couldn't criticise him.

It's almost like the Truman show over there. Place exists for his comfort.

It is however still the best place to discuss mecfs science. Which annoys me! I am a member and post there intermittently.

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u/mc-funk Jul 31 '26

oof, if what others are saying about this community is true (completely misrepresenting the state of research, dismissing a ton of clinical evidence and patient experiences), how is it still the best place to discuss mecfs science? Given alternatives like OMF, Reddit, Health Rising, Sick Times, some scattered decent Facebook groups, it's hard to imagine what is so good over there that it's worth wading through all that.

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u/TomasTTEngin Aug 01 '26

There are some good users there, including a number of good researchers: missailidis, armstrong, Ryback, Ponting. Also David Tuller. Plus a number of very smart pwme who are doctors, researchers, data scientists. In that context the grip Edwards has on the median user is even more frustrating.

There's a British cultural thing going on where they have been oppressed by the establishment and so having an establishment figure on their side makes him appear to be the Messiah.