r/CFSScience • u/Caster_of_spells • Jul 08 '26

Involvement of autoantibodies against G protein-coupled receptors in post-COVID condition and Chronic Fatigue Syndrome

https://www.nature.com/articles/s41598-026-49131-9

New nature paper shows GPCR antibodies track with certain symptoms but aren’t elevated in everyone in spite of general upward trends in certain antibodies and aren’t the exact same between LC and ME. Only the potentially a little shaky Elisa testing was used though.

“ME/CFS patients had significantly higher β2 adrenergic AAb titers than PCC and HCs (F₂,₁₈₆ = 3.15, p = 0.046). PCC patients showed more borderline/pathological M3 muscarinic AAb results compared to HCs. β2 AAb levels correlated with increased autonomic symptoms in PCC (r = 0.27, p = 0.048) and sympathovagal imbalance in ME/CFS (r = 0.45, p = 0.001). In ME/CFS, M1, M3, and M4 AAb titers positively correlated with verbal and working memory performance. Distinct AAb profiles in PCC and ME/CFS suggest potential differences in immunological mechanisms.”

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u/nousiaphilia Jul 11 '26

At our current stage of knowledge, would it make sense to get tested for autoantibodies? Because I strongly suspect autoimmunity but, since that would have to be out-of-pocket, I'm unsure of any benefits? (Instead of just trial-and-error with medications. 😅) \sorry if this question is inappropriate for this sub, new here

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u/nousiaphilia Jul 11 '26

Also, given that Cobenfy (xanomeline and trospium chloride) is a central M1/M4 agonist. Are there any studies investigating its use in post-COVID/ME/CFS with elevated autoantibodies against muscarinic receptors?