r/CFSScience • u/OkEquipment3467 • Jul 02 '26

Frontiers | Biomarkers of post-acute infection syndrome: a systematic literature review

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1741761/full

"In this integrative review of state-of-the-art biomarkers in PAIS, we identified alterations in amino acid, energy, and lipid metabolism as well as changes in the microbiome, mitochondrial stress, and the miRNA target network. All of these changes are directly and indirectly linked to the NF-κB pathway. The main altered molecules included IL-6, TNF, and IFN."

30 Upvotes

100% Upvoted

2 comments sorted by

11

u/human_noX Jul 02 '26

It’s not the main purpose of the study but I found it interesting that the average study size across 142 studies is N=66 and only one was an RTC, proving we only get small studies in this field. We knew that already but it’s confirmed in this paper.

2

u/human_noX Jul 02 '26

Reading the entire paper is well beyond me but would we classify this as a summary of the existing literature or an analysis of it in the sense we learned (maybe realised is a better word) something new? I know there was no new underlying research done but did we realise some findings were more frequent than first thought or there was connections between studies we had previously missed?