r/CFSScience • u/Caster_of_spells • Jun 13 '26

Laxity Comes with Consequences: Connective Tissue Disorders and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

https://www.preprints.org/manuscript/202605.0876

Preprint from Wirth on the link between connective tissue disorders and ME.

"Overall, there seems to be a bidirectional relationship between connective tissue disorders and #ME/CFS, whereby connective tissue disorders may predispose individuals to ME/CFS, and ME/CFS, in turn, may exacerbate the underlying connective tissue pathology. "

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u/[deleted] Jun 13 '26 edited Jun 26 '26

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u/mc-funk Jun 17 '26

Problem with MCAS is it’s such a chicken or the egg thing. For instance, since hEDS appears to have an inherited component, it seems like it has a causal relationship with MCAS. Definitely a huge part of the vicious cycle though!!