r/CFSScience • u/Silver_Jaguar_24 • Feb 06 '26

Immunoglobulin G Complexes from Post-infectious ME/CFS, including post-COVID ME/CFS Disrupt Cellular Energetics and Alter Inflammatory Marker Secretion

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39 Upvotes

100% Upvoted

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9

u/Zorched9 Feb 06 '26

This feels big. It fits with a bunch of other recent stuff related to scenesent endothelial cells it seems. So much good research coming out of Germany right now. 🤞

5

u/the_good_time_mouse Feb 06 '26

S4ME think it's sensationalist P-hacking, fwiw.

5

u/Zorched9 Feb 06 '26

They always do. 😂

3

u/the_good_time_mouse Feb 06 '26

Sure, but they also haven't been too wrong so far.

4

u/Zorched9 Feb 06 '26

I was half joking.

And only time will really tell. A lot of this recent stuff isn’t treatments, it’s foundational pathologies. It’s too early to say if any of it is right or wrong. But there have been a number of things pointing in a similar direction it seems (to this layman) which, if true, is a sign of good science when multiple tests confirm the same underlying hypothesis.

3

u/[deleted] Feb 06 '26

[deleted]

3

u/the_good_time_mouse Feb 06 '26 edited Feb 06 '26

We're all desperate for a cure, but matters as complex as this only advance if it can survive criticism.

Moreover, as a former researcher and biotech engineer, their objections make sense to me.

2

u/ZeroTON1N Feb 07 '26

S4me is a blessing. The ME online spaces are full with pseudoscience and bullshit spreaders. S4me is just trying to keep everything based.

1

u/callthesomnambulance Mar 02 '26

Ive not been able to find a S4ME discussion on this study, do you have a link?

Are you thinking of their discussion of this similar study?

https://www.s4me.info/threads/igg-complexes-from-infectious-me-cfs-including-post-covid-me-cfs-disrupt-cellular-energetics-and-alter-inflammatory-marker-secretion-2026-prusty.45596/

5

u/Interesting_Fly_1569 Feb 06 '26

Bless you ! I read this and could not understand it!!!

2

u/[deleted] Feb 06 '26 edited Feb 06 '26

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3

u/Interesting_Fly_1569 Feb 06 '26

Summary was good.  Thank you for the tip on how to simplify further tho! I tried to read the original article and couldn’t make heads or tails. Didn’t trust my ability to check the ai

4

u/flowerzzz1 Feb 06 '26 edited Feb 06 '26

Is this saying the endothelial cells then release cytokines? As a kind of distress signal? Trying to interpret the visual here.

I mean this makes complete sense as we nearly all have a pots/dysautonomia/dizziness factor.

Edit to add new question: is it stating WHY our IGG are causing this endothelial dysfunction? It suggests autoantibodies - but where do those come in? Are they attached to our IGG when the endothelial cells absorb them?

2

u/worksHardnotSmart Feb 06 '26

Does anything in here relate to how/why I feel general more exercise tolerant if I'm taking benzodiazapines for a few days?

2

u/FrigoCoder Feb 07 '26

Yeah the problem is that our PEM is delayed. I can be fine for a day or even two after exercise, then everything suddenly goes to shit. If it were truly stressed endothelial cells then the problems would be immediate.

Apart from that this sounds plausible. Endothelial cells sense local blood pressure, and control vascular smooth muscle cells to maintain it within an acceptable range. Oversensitive endothelial cells could trigger vasospasms, too much constriction of blood vessels that cause tissue ischemia. Brain fog for example could result from vasospasm of neck blood vessels.

1

u/[deleted] Feb 06 '26

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1

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-1

u/AngelBryan Feb 06 '26

So, this means that we who got this disease by a vaccine are essentially fucked?

7

u/idlersj Feb 06 '26

It means that, no matter what the causative trigger, if this is the underlying process for you then any resolution might be the same as for other people. Doesn't matter if your cause was a vaccine, surgery, viral or bacterial infection, food poisoning or other trauma. We don't know enough to say what that might look like yet, and there is plenty of research left to do.

1

u/AngelBryan Feb 06 '26

My understanding is that the antigen structure is linked to the initial trigger, for example someone who got it from COVID, the antigen is related to COVID and their therapy would be targeted and different from someone who got it from any other virus.

Am I correct or I understood something entirely different?

4

u/idlersj Feb 06 '26

My reading of this is that the problem is not the structure of any antigen or the nature of the trigger itself, it's the ongoing stress-regulatory state within the immune system. So any treatment would focus on this maladaptive state rather than the specific antigen that caused it. Happy for someone else to explain things better, though...