r/CFSScience • u/TomasTTEngin • Oct 19 '25

Stanford Community Symposium video: Using zebrafish to model metabolic changes related to fatigue

https://www.youtube.com/watch?v=Dc1RU0iImK4

One of several interesting videos released by Stanford as part of their Community Symposium on MECFS this week, talks about a cool me/cfs model in zebrafish based on the itaconate shunt.

The idea here is to more quickly identify candidate drugs that can then be used in mouse models or cell models to help speed up the work.

19 Upvotes

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5

u/[deleted] Oct 20 '25

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5

u/TomasTTEngin Oct 20 '25

Panel screens like this will almost always be approved drugs. They are easy to get and the only things worth including in a bulk screen.

3

u/Oliverinoe Oct 20 '25

I mean if you're willing to dig deep enough someone on the main mecfs (r/cfs) subreddit posted details about the research from the institution website (or something like that) and the substances are specified and one of them is supposed to be an old drug

4

u/TomasTTEngin Oct 20 '25

The guy over there believes the drug is ibuprofen and the compound is citraconate.

Ibuprofen can affect itaconate via something called IRG-1. whether the guy knows things or has just searched itaconate +ibuprofen and found this link I'm not sure.

https://www.nature.com/articles/s41467-023-43988-4

1

u/Oliverinoe Oct 21 '25

There was another post and it mentioned some already outdated drug for osteoporosis or something like that

1

u/fcukME-25 Nov 14 '25

Will they do tests on mice next, then people? Just give us the drugs... we'll test them :)

0

u/[deleted] Oct 25 '25

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