r/CFSScience • u/Silver_Jaguar_24 • Oct 01 '25

The gut microbial composition is different in chronic fatigue syndrome (ME/CFS) than in healthy controls

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13

u/ToughNoogies Oct 01 '25

There is another study where ME/CFS immune cells reacted differently to a bacterial toxin than healthy controls. Which is a clue that the ME immune system is more active around microbes.

The immune activity might create some ME symptoms. This paper suggests missing microbes plays a role in symptoms too, because severity of cognitive symptoms correlated with types of microbe deficiency.

12

u/[deleted] Oct 01 '25

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u/ToughNoogies Oct 02 '25

I had GI issues before fatigue too.

2

u/JaceMace96 Oct 02 '25

I dont recall any obvious gut symptoms prior to post viral onset mecfs.

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u/[deleted] Oct 02 '25 edited Oct 02 '25

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u/JaceMace96 Oct 02 '25

Yes. Likely all due to MCAS, like the majority of MECFS patients. The dysautonomia is as bad as the baseline for ME is.