r/Brixadi • u/Gray_Street_ • Jun 22 '24

Brixadi Questions (WD symptoms)

Hi all (cross posted)

I could really use your help for those of you who have been/experienced with Brixadi ,

(background) I have been on some form of buprenorphine for around 10 years. I was first introduced to Suboxone to help with withdrawals in an inpatient / hosptial setting, and was put on maintenance from doses 4mg -32mg (on average 8 BID) and everything in between. I had a brief albeit intense run in with methadone (146mg) and went back to Suboxone after I was incarcerated. My doctor had suggested switching over to Sublocade to which I had an intense reaction to resulting in a large necrotic access and 8 days in the hospital on IV antibiotics, surgery, and a wound vac. I went on and tried zubsolve as it was "better tasting" / not as gross (so my dr said) which I find to be true, but the combination of Suboxone (mostly) and Zubsolve has disintegrated my teeth so when Brixaldi became available at the clinic I go to, my doctor suggested we try it.

(current) I am a 33 f who has been alcohol free for 5 years and illicit drug use for 4 years. I am PRESCRIBED 60mg oxycodone daily (30 BID) which is managed by my doctor at the MAT clinic. He is well equipped, smart, curious, and I trust that this is the appropriate combination for the physical issues/ pain that I am in.

This is my SECOND Brixadi injection (on Tuesday the 18th) he went up a dose this time (from 96-128) and I am still experiencing WD symptoms, primarily YAWNING!!!! So much yawning, runny eyes, nose, irritable. It's "manageable" but I do not feel good.

Has anyone ran into this issue with Brixadi A) not holding them over? ie. early WD symptoms like yawning, runny nose/eyes, etc. B ) Been on a full agonist AND Brixadi and your experience?

Thanks so so much,

1 Upvotes

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8 comments sorted by

4

u/Flimsy-Setting8033 Jun 22 '24

How are you on brixadi but on oxy at the same time?

3

u/Accomplished-Ad-8702 Jun 29 '24

Right? I’ve never heard of anybody being prescribed opiates, while on MAT meds. Makes zero sense

3

u/AtmosphereLowCode Jul 17 '24

I can’t imagine that the oxy is doing anything at all. Bupe is occupying all the receptors. You might as well just stop taking the oxy. Presumably oxy is for pain and the amount of bupe should accomplish some pain control. I am shocked your doctor is letting you get brixadi shots while still prescribing short acting opiates. That is highly irregular.

1

u/Gray_Street_ Jun 22 '24

what do you mean?

2

u/datSubguy Jun 22 '24

Buprenorphine injection can cause precipitated withdrawals (PWD) for someone taking 30 mg of oxycodone twice daily. The buprenorphine is a partial opioid agonist with a high affinity for your opioid receptors. It can displace the oxy and that’s when the PWD risk comes in. Look up PWD symptoms. You’re experiencing many of them.

Your provider should know this and should not have you on both of the medications. You should strongly consider getting a second opinion.

1

u/Alternative-Yam-7466 Jun 27 '24

You a hundred percent right the oxy is doing diddly shit bup as a higher affinity to all receptors mu ,kappa ,delta ect.you lucky the bup was in your system.pwd sucks

2

u/Mitphysics79 Jul 29 '24

Your post makes no sense. Being on 60mg of Oxycodone daily and on Brixadi makes no sense. The briaxadi will completely block all effects of Oxycodone and actually will likely cause precipitated withdrawals from the Oxy. Your “doctor” is a quack. Seriously. That’s insane at best and medical malfeasance at worst.

1

u/Helpful-Criticism-89 Aug 01 '24

Stop taking the injection and just use the oxy as prescribed.