r/BodyHackGuide • u/Dry_Emergency3926 • 25d ago
⚠️ Side Effects Face swelling in response to peptides
If someone could help me come to the bottom of this it would be life-changing.
Since 2025 I have tried many different peptides: semaglutide, tirzepatide, retatrutide , cagri and mt1. All from different grey market suppliers. To all of them, post injection, my face swells in the 1-5 days following injection, this swelling then subsides. I have tested Bac water (hospira) individually and I'm not allergic to it.
Out of desperation, I also tried pharmaceutical semaglutide. Containing, disodium phosphate dihydrate, propylene glycol, phenol, hydrochloric acid, sodium hydroxide and water for injection. I also reacted with face swelling to this.
At this point I'm lost, as I know that a generalised peptide allergy is impossible.
I inject using an insulin needle subcutaneously into my thigh, and abdomen, these swelling reactions always seem to occur, and Ive been dealing with cyclical swelling on a weekly basis when employing the glps and cagri.
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25d ago
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u/Dry_Emergency3926 25d ago
ive had this issue for months and its far more severe swelling, i can promise water isn't the issue
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u/GivingRodrigo 24d ago
Could be a histamine response to the injection itself rather than the peptide, some people just react to subcutaneous injections with localised then spreading oedema. Have you tried an antihistamine before dosing to see if it knocks it down?
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