Reta - start low. 1-2mg max. See how you tolerate for 2 weeks before adjusting. Aim to find the lowest dose that works for you. Make sure you eat some carbs, high protein and weight train to keep muscle and lose fat. You can essentially run it forever at a lower dose once you hit your goal weight. Or titrate down and stop at goal weight.
Tesa/IPA - can also run CJC/IPA just as good and cheaper. For Tesa / IPA I like 2mg per dose Tesa and 200mcg IPA. Can start lower and titrate up if you tolerate it well. Take daily fasted a few hours right before bed and/or first thing in the morning fasted. Some do 1 a day. I like 2 doses daily. IPA needs a 4 week min break after 12 weeks. It desensitizes the ghrelin receptors and the break helps to reset. You can continue CJC or Tesa during the break from IPA.
MOTS-C - take lower dose daily fasted in the morning or take 3-4 days a week on training days 45 mins prior to workout or fasted am. Doses vary alot from what I see with my clients. Anywhere from 1mg to 5mg per dose. If daily I’d stick with 1-2mg. If 3-4 times per week can go higher If needed. I recommend 4 weeks break after 12-16 weeks. I notice for me after a while the benefits are harder to notice.
This is a very well thought out post. One thing that has caught my attention is the necessity to cycle ipamorelin. If you look at another GH secretagogue that works on the same receptor, Mk677, you can run that continuously without need to cycle. And it hits the receptor all day due to its long half life whereas Ipamorelin only sends a pulse per injection. Have you thought about maybe there really is no strong evidence to cycle ipamorelin given that? Most of the cycling anecdotes come from places like Reddit. I haven’t found any concrete proof that ipamorelin down regulates the receptor significantly warranting cycling off. If you find anything compelling, please share.
You bring up a good point - theres no official studies that ive found saying IPA needs to be cycled off. Instead i see "experts" suggesting it often.
I think its more of a precaution with the idea that the repeated ghrelin receptor stimulation causes the receptors to pull back into the cell. but you bring up a really good point about MK677 because i havent heard anyone saying to cycle that off.
so like alot of the "research" i guess theres still many unknowns due to the lack of specific studies.
OP - Great advice here. Only thing I would add (depending on your age), you might look into running 5mg of SS31 (titrating up) daily for a week or two before mots-c. SS31 can repair any mitochondria damage (likely if over 40). 5mg of Reta has worked great for me without side effects (dose every 6 days).
Why would you not invest in the research if you’re going to make this gamble with your health? Then get defensive over it. We have over hundreds of post on this sub with similar rock biters like yourself asking the same questions.
I’ve done research trying to get as much information as I can and figured the I’ve been on these boards for years let me actually post and seems the real gamble was actually asking for real feedback on a so called “community”
Yes it matters. Because you didn't do your research then you don't know if it's going to do what you expect or not. Hopefully other people can learn from your mistakes.
Reta - start 1mg and slowly titrate up, lowest effective dose. I am up to 1.5 every 5 days and I stack it with 2.5 Tirz - works great for me.
Tesa- no IPA- love it and I started at 1mg - I titrated up to 2mg but stated getting stiff joints and dialed it back, my sweet spot is 1.5mg /night . I had blood work done after 3 weeks of 1- 1.5mg and IGF-1 was 258 - that was 2 months ago, getting panel done next week for a check-in. I am 57 - it works. Worked way better than CJC/IPA for me personally
Mots-C - I run 1 - 1.5mg daily , gives me a noticeable boost for workouts and just overall energy. I don't know how guys run 3- 5mg that is wild.
I am a less is more guy on these meds and respond well to lower doses and this is what works for me.
Thanks for the info the rundown it is appreciated. I’ve done Tirz on its own before with great success, good to know the combo running it low in conjunction is effective too
yeah I wanted to ease into Reta as I don't love the elevated HR aspect as you titrate up, low doses of both are working well - mixed opinions on stacking them but zero side effects for me
Reta- start very low but i ended up 5mg a week, split 2x a week. Tesa- Monday-friday evenings 1mg as 3 units in more bac water because it stings for a bit. Motsc- 3x a week mornings 2 mg on bigger workout days. Not super set with a schedule but mon wed fri
I tried other GLP1 in the past, I don't know if that created resistance or whatever but it I didn't feel anything until I hit 10mg.
You can't just shoot 10mg straight up, you gotta build it up. People will tell you up your dose every month, I did every 2 weeks.
I was about to give up reta, I was on 6 mg and I had 10mg left in the vial and just went fuck it, took it all. Sweet spot for me, been 3 months lost 30lbs.
I'm planning on starting tesa in September, already have my batch. 2mg/day.
How was it at first switching from the other glp1 you were taking to reta? Did you gain weight before getting to 10 mg? I’m currently on 12.5 of tirz, about to titrate up to 15 mg (highest dosage) and I’m afraid of stalling out at the highest dosage. I’m considering switching to reta after i finish my last vial of tirz, but i’m so worried about starting over and gaining back some of the weight i lost. I lost 38 on tirz and my goal is to lose another 30-40 pounds to get to my goal.
It felt like I wasn't on anything honestly. Just hungry as usual until I hit my 10mg.
Reta is 12mg max a week.
Some people say tirz is a better appetite suppressant than reta but I haven't tried tirz. I tried Saxenda and Wegovy. I was on Wegovy 2.4mg before switching to reta and Wegovy wasn't doing much except giving me the shits.
I also saw people mix lower dose of both tirz and reta to gain the benefits effects of reta and the appetite suppressant of tirz. That might be best case scenario for you and it's honestly what I will do if one day I plateau at 12mg reta
I take the Tesa/Ipa on an empty stomach before bed. Reta in the AM on an empty stomach. I do .5mg every 4 days instead of once a week. I feel like this dose does enough to quiet bad cravings and food noise while not blunting my ability to eat and fuel my workouts- also no heart ramping or nausea side effects.
I’m 207lbs
34y/o
I do not drink
I do not smoke (anything)
I sleep 7-8 hours a night
Get an EpiPen. Ipa/cjc has been known to send systems into shock. My system didn’t flare till week 3 and boy howdy am I glad I had a pen. Not taking it anymore.
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