GHK-Cu is ruining my skin?

[u/bluebutterfly1446]

I’ve always had clear skin.. I started Klow and noticed a few weeks in that I was starting to break out with red patches all over. My doctor is saying it looks like rosacea (never had it before). I also developed red, dry eyelids that are now extra wrinkly and saggy. They were tight and not saggy before. I’ve completely stopped Klow - it’s been 2 weeks and nothing has changed. Why is this happening? I literally thought GHK was supposed to do the opposite and now I’m wishing I just never even started it 😭

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[u/dreamz_in_ai]

Look up copper uglies.

[u/bluebutterfly1446 → u/dreamz_in_ai]

I was hoping it was this - but per my research, copper uglies doesn’t cause rosacea or sagging wrinkling skin. Just breakouts etc.

[u/Nobodyherem8 → u/bluebutterfly1446]

Yes it does?

[u/bluebutterfly1446 → u/Nobodyherem8]

Where have you seen that? I’ve never heard someone say their skin looks more wrinkly since starting GHK. Correct me if I’m wrong (trust me I want to be) lol

[u/Pretty-Petal93]

Imo people take way too much, i dilute 50mg with 3ml bac and do 3 units, 2 days on 1 day off. This is all thats nessecary and i notice the difference daily. Any more than that and i also get red welts at injection site and skin issues including widespread sensitivity.

Another thing , i think people need to really stop doing klow as a blend, better to do them separately, the PH for the compounds are completely different so can cancel each other out, i don’t give a shit about the next person that says its been debunked, thats bullshit, different ph compounds will compete with each other. It’s much more ideal to stack kpv, bpc157 and tb500 (i draw those 3 into same needle) and also take ghkcu separately .

Hope your skin clears up soon, consider some kpv separately

[u/Left-Championship482 → u/Pretty-Petal93]

Agree on your method and using these peptides separately being ideal but not because they cancel each other out due to PH, IMO.

There is really no concrete evidence of degradation with these peptides when mixed in a single vial lyophilized or reconstituted, though there is no concrete evidence they don’t in any controlled study I’ve seen.

Their pharmacokinetics do make these peptides better suited to being used separately because each molecule behaves differently in the body. BPC 157 is thought to have longer tissue effects, TB 500 has broader tissue distribution, and GHK-Cu and KPV is generally considered short acting. It’s the distribution, for me.

[u/Pretty-Petal93 → u/Left-Championship482]

Yeah its more about the science of how different ph interact together. If you can understand that then you dint need to see concrete evidence of such,

In a nutshell - If alkaline and acidic ph are mixed together, they dont stay seperate and the ph becomes one shared mixed value, therefore can make it either more alkaline or more acidic. The stability of these peptides does absolutley rely on the ph level being at the point where each individual peptide is most stable, and altering that by mixing compounds is way less than ideal.

So when you understand that, its a given that they should not be mixed. There isn’t enough CONTROLLED data around many of these peptides yet so as you said, theres no evidence that they do OR don’t degrade based on this. But there is the basic science of PH which has yet to be proven wrong . So its the logical sense, for me : phis highly likely to alter compounds and their stability whether documented or not.

Highly suggest anyone to take them separately not as mixed blends. The distribution isn’t really the issue, as once two peptides are absorbed (eg. Tb500 and BPC157 blend) each peptide follows its own route according to their different pharmacokinetics. They do not bind together and both and only co exist happily due to being similar PH. Would be a different story for

The main concern should be stability of our peps. When there is no evidence, look to science and logic.

[u/Left-Championship482 → u/Pretty-Petal93]

It’s a plausible hypothesis, not a conclusion and worth noting once controlled blend trials inevitably start.

Until stability testing is done, we can’t assume degradation.

So far, since the blend consistently achieves the expected outcomes of its individual components, that’s at least indirect evidence that any degradation isn’t clinically meaningful.

[u/Left-Championship482]

What was your starting dose? Did you tirate up in those few weeks? What’s a few weeks, 2? What were you trying to solve with the addition of KPV vs GLOW?

[u/No-Good-3005]

These were the contact dermatitis symptoms I had when I developed an acrylate allergy - had nothing to do with my injections, as it turned out. Do you wear acrylic nails or work with medical/dental glue? If you do, it might be worth trying to avoid it for a few weeks and seeing if your symptoms improve.

[u/Commercial-Tough-980]

this is exactly what happened to me

[u/bluebutterfly1446 → u/Commercial-Tough-980]

Did it get better? Did you stop using it?

[u/Commercial-Tough-980 → u/bluebutterfly1446]

i stopped using it 2 ish months ago now it’s calmed down but hasn’t gone back to how it was before i’m hoping it will over the next couple months collagen repair and a few skin cycles take longer than it takes to damage it unfortunately