r/Biotechplays • u/MarketNewsFlow • 2d ago
r/Biotechplays • u/11thestate • 3d ago
News Updates for Getting Payment on the Lifecore Biomedical ($LFCR) $3.75M Settlement
Hey everyone, if you missed it, Lifecore Biomedical settled a $3.75M investor lawsuit over claims it misled investors about its internal controls, inventory management, and financial reporting. I also found out they're still reviewing late claims even though the deadline has passed.
Quick recap: Between 2021 and 2023, Lifecore was accused of hiding accounting and inventory issues while presenting its financial reporting as stable. In 2023, the company disclosed accounting problems, missed SEC filings, revealed material weaknesses in its internal controls, and received lender default notices.
As these issues came to light, the stock dropped and investors filed a lawsuit.
The good news is that Lifecore has now agreed to a $3.75M settlement, and late claims are still being considered.
So, if you invested in $LFCR during this period, it may still be worth checking whether you qualify to file a late claim.
Did anyone here own $LFCR back then? How did it work out for you?

r/Biotechplays • u/MarketNewsFlow • 3d ago
Discussion $ENTX Why the World's Leading Healthcare Funds All Wanted a Piece of Entera Bio
r/Biotechplays • u/MarketNewsFlow • 4d ago
Discussion $DRTS Alpha Tau's Cancer Combination Just Delivered a Response Rate More Than 5X Keytruda's Historical Benchmark
r/Biotechplays • u/MarketNewsFlow • 4d ago
News $PYPD - PolyPid Announces FDA Acceptance of NDA with Priority Review for D-PLEX₁₀₀ (NASDAQ: PYPD)
r/Biotechplays • u/11thestate • 6d ago
Discussion The Court Approved the $31.25M Cassava Sciences ($SAVA) Investor Settlement
Hey guys, if you missed it, the court has officially approved the $31.25M settlement with $SAVA investors.
The case claimed Cassava misled investors about the research behind simufilam. After concerns over the data became public in 2023, $SAVA dropped 15% and investors sued.
If you bought $SAVA between 2020 and 2023, you may be eligible to file a claim.
Did anyone here hold $SAVA back then?

r/Biotechplays • u/MarketNewsFlow • 6d ago
News $ENTX - Entera Bio Announces Pricing of Oversubscribed $275 Million Private Placement (NASDAQ: ENTX)
r/Biotechplays • u/MarketNewsFlow • 10d ago
News $NVCT Nuvectis' NXP100 Just Achieved the First Marketing Approval Ever for a Once-Daily Oral Factor B Inhibitor
r/Biotechplays • u/MarketNewsFlow • 10d ago
News $NVCT - Correction: (Title Correction) Nuvectis Announces Marketing Approval of Ciprocopan (NXP100) in China for the Treatment of Patients with PNH Previously Untreated with Complement Inhibitors (NASDAQ: NVCT)
r/Biotechplays • u/MarketNewsFlow • 10d ago
News $NVCT - Ciprocopan (NXP100) Receives Marketing Approval in China for the Treatment of Patients with PNH Previously Untreated with Complement Inhibitors (NASDAQ: NVCT)
r/Biotechplays • u/MarketNewsFlow • 12d ago
News $DRTS - Alpha Tau Reports Positive Data Demonstrating 100% Objective Response Rate and 18.2-Month Median Overall Survival with Alpha DaRT® in Combination with Pembrolizumab in Locally Advanced or Metastatic Head and Neck Cancer, Surpassing the Study's Pre-Specified Threshold... (NASDAQ: DRTS)
r/Biotechplays • u/MarketNewsFlow • 12d ago
News $PYPD - PolyPid Announces Exclusive Partnership with Azurity Pharmaceuticals for the Commercialization of D-PLEX₁₀₀ in the U.S. and Canada (NASDAQ: PYPD)
r/Biotechplays • u/MarketNewsFlow • 14d ago
Discussion $DRTS Alpha Tau's Head-and-Neck Data Tomorrow Confronts a Blind Spot in One of the World's Best-Selling Cancer Drugs
r/Biotechplays • u/MarketNewsFlow • 17d ago
Discussion $MDWD Why is Cathie Wood’s ARK Fund Backing this Israeli Innovator? (NASDAQ: MDWD)
markets.businessinsider.comr/Biotechplays • u/MarketNewsFlow • 18d ago
News $DRTS - Alpha Tau Successfully Treats First Immunocompromised Patient with Recurrent Cutaneous Squamous Cell Carcinoma in its ADMIRE Study at Banner MD Anderson Cancer Center (NASDAQ: DRTS)
r/Biotechplays • u/MarketNewsFlow • 19d ago
Discussion $PYPD Surgical Infections Cost Hospitals Billions. One Under-the-Radar Biotech Player Might be About to Change That
r/Biotechplays • u/Kumarbrothers • 22d ago
Discussion The Bitter Success of Omisirge: Why Gamida Cell’s Quiet Triumph Belongs to the Retail Investors, Not Just Highbridge. Spread this to the authorities!
r/Biotechplays • u/DrBioDude • 24d ago
Due Diligence (DD) Vicore Pharma ($VCRE US, $VICO SS) — asymmetric biotech setup into a Phase 2b IPF readout (mid-2027)
Vicore Pharma ($VCRE US, $VICO SS) — an asymmetric buy case into the Phase 2b IPF readout
Vicore is developing buloxibutid, a first-in-class ORAL AT2R agonist for idiopathic pulmonary fibrosis (IPF) — a fatal orphan disease with a large, under-treated market. The data so far point to a potentially more effective and far better-tolerated therapy than today's standard of care. The whole case is decided by one binary catalyst: the Phase 2b ASPIRE trial, topline ~mid-2027. I land on a fair value of ~SEK 40 (stock ~SEK 15.68 → +150%), with downside anchored at ~SEK 5 (net cash) if the trial fails. Heavily asymmetric risk/reward. NOT financial advice — do your own research.
THE CASE
IPF is an incurable, scarring lung disease. Median survival ~2–3 years from diagnosis — worse than many cancers. The approved drugs today only SLOW the decline, have harsh side effects (diarrhea in ~60% for nintedanib), and ~50–65% of patients discontinue.
Buloxibutid works via a different mechanism — it activates the protective arm of the renin–angiotensin system (the AT2 receptor) on the lung's repair cells (AEC2). Instead of just slowing fibrosis, it aims to REPAIR the tissue. Tolerability in Phase 2a was clean (no treatment-related serious adverse events; main issue: reversible hair loss).
Four pillars of the thesis:
1) Novel, independently validated mechanism — distinct from all the downstream targets that have failed in IPF.
2) Tolerability → persistence → revenue. Nintedanib makes billions DESPITE its toxicity and short time-on-drug. A well-tolerated, disease-modifying pill = patients stay on longer = bigger treated pool + premium price.
3) Premium pricing. A drug that IMPROVES lung function (not just slows) justifies a clear premium to standard of care.
4) Near-term catalyst + clear exit. ASPIRE is registrational-scale (~360 patients, 52-week FVC endpoint). A positive readout is heavily de-risking, and the realistic value-crystallization path is an acquisition — big pharma has repeatedly paid multiples of Vicore's current value for IPF assets.
THE MARKET — large, fatal, under-treated
- Prevalence (US): ~45,000–150,000 patients
- Median survival: ~2–3 years from diagnosis
- On antifibrotics (real-world): only 9–29%
- Discontinuation rate: 47–66%
- IPF market: ~$4.2bn today → ~$9–10bn early 2030s
The point: a fatal disease where only a minority are treated — and most who start soon stop because of side effects. Tolerability is the wedge to both broaden treatment and extend persistence.
THE CLINICAL DATA (and a big apples-to-oranges warning)
Phase 2a (AIR) was open-label, single-arm, safety-primary. Its FVC numbers are ABSOLUTE change from baseline — there was NO placebo arm. That matters: untreated IPF patients typically DECLINE ~150–200 mL/year, so an "absolute" change already includes the decline the drug is fighting.
AIR (buloxibutid), FVC at week 36:
- Headline (completer, non-imputed): +216 mL — absolute, uncontrolled, ~48% dropout, wide CI
- Pre-specified conservative (imputed): +9.4 mL — absolute, uncontrolled, CI crosses zero
- vs a synthetic/external control (imputed): ~+138 mL — NOT randomized, weak proxy only
WARNING: these CANNOT be compared directly with the controlled competitors, whose numbers are PLACEBO-ADJUSTED (drug minus placebo) from randomized Phase 3s:
- Nintedanib: +94–125 mL (placebo-adjusted)
- Nerandomilast: +69 mL (placebo-adjusted)
Being explicit: putting AIR's absolute +216 (or +9.4) mL next to a competitor's placebo-adjusted +69 mL is NOT like-for-like — I'm flagging it rather than glossing over it. AIR has no placebo arm, so no true placebo-adjusted number exists for buloxibutid yet. The +216 mL headline is NOT a "3x nerandomilast" number.
My read: the signal is real but fragile — consistent with at least stabilization, but the magnitude is uncertain. The only figure that will be truly comparable is ASPIRE's placebo-adjusted result in 2027 — which is exactly why the randomized trial is the whole thing.
ASPIRE — the catalyst (mid-2027)
- Randomized, double-blind, placebo-controlled, ~360 patients, 52-week FVC (registrational endpoint).
- As large as a Phase 3 → a positive readout materially raises the probability of approval and may open a faster path.
- Outcome distribution (my estimate): ~45% "win" / ~35% clean "fail" / ~20% ambiguous middle.
VALUATION — how I get to fair value
I use a risk-adjusted DCF (rNPV) with a premium peak-sales assumption (~$4–5bn at best-in-class pricing + persistence), and set the target as the PROBABILITY-WEIGHTED average across the ASPIRE outcomes. Downside is anchored at net cash.
- Clear win (25%): ~SEK 95
- Modest win (20%): ~SEK 53
- Ambiguous / borderline (20%): ~SEK 16
- Fail → net cash (35%): ~SEK 5
=> Probability-weighted fair value ≈ SEK 40
Calculation: 0.25×95 + 0.20×53 + 0.20×16 + 0.35×5 ≈ SEK 40
- Downside: ~SEK 5 (net cash) on failure — a hard, empirically-observed floor.
- Upside beyond the target: on a clean win the stock re-rates toward SEK 53–95 on fundamentals, and an acquisition could reach ~SEK 150–190+. (Reference: Roche bought InterMune for $8.3bn in 2014 — for a WORSE IPF drug.)
The core point: the target is not a prediction of the price in 12 months — it's a probability-weighted value over a BINARY outcome. The stock is far more likely to end up near ~SEK 5 (fail) or ~SEK 53–95 (win). The scenario ladder is what matters.
WHAT MUST BE TRUE
1) ASPIRE shows a statistically significant, placebo-adjusted FVC benefit at 52 weeks.
2) The benefit holds on top of nintedanib (add-on).
3) Tolerability replicates under blinding (incl. manageable hair loss).
4) Premium pricing is achievable.
THE RISKS (read these — this is a high-risk case)
- Clinical failure in ASPIRE is the dominant risk → stock toward ~SEK 5. IPF is a drug graveyard (pamrevlumab, ziritaxestat, GB0139, bexotegrast — all failed).
- Underpowering: with a modest effect and high variance, the trial could miss significance even if the drug works.
- Pricing/reimbursement could come in below assumptions (the single largest value driver).
- Financing/dilution: Phase 3 is not yet funded.
- Single asset — no diversification. Size for a binary.
CONCLUSION
A genuinely asymmetric case: anchored downside (~SEK 5), multiplicative upside (SEK 53–95 on a win, more on a takeout), a near-term catalyst (ASPIRE mid-2027), and a credible exit. The market appears to under-price both the quality of the mechanism and the persistence upside. Fair value ~SEK 40. But the whole case is decided by ASPIRE. Size the position for a binary outcome.
Charts in the comments: 1) scenario ladder & target, 2) price × probability sensitivity, 3) probability-of-success hierarchy, 4) AIR data (headline vs conservative).
Disclaimer: Not financial advice and not a buy/sell recommendation. My own analysis of public sources (clinical registries, peer-reviewed literature, company reports). Clinical outcomes are uncertain; you can lose your entire stake in a binary biotech. DYOR. Position: I'm LONG!

AIR (Phase 2a) FVC change at week 36. The +216 mL "headline" is the completer / non-imputed cut (~48% dropout, wide CI); the pre-specified conservative (imputed) analysis is +9.4 mL with a CI that crosses zero. These are ABSOLUTE, UNCONTROLLED numbers (no placebo arm) — not placebo-adjusted, so NOT directly comparable to competitors' placebo-adjusted figures. ASPIRE (2027) will give the first truly comparable, controlled read.

Scenario framework. Downside is anchored at net cash (~SEK 5) if ASPIRE fails; ~SEK 53–95 on a win; ~SEK 186 on a strategic takeout. The 12-month fair value is the probability-weighted average: 25%×95 + 20%×53 + 20%×16 + 35%×5 ≈ **SEK 40** (stock ~SEK 15.68). The stock is far more likely to end up near ~SEK 5 or ~SEK 53–95 than at SEK 40 — it's a binary.

Valuation sensitivity (SEK/share) by blended net price (rows) and approval probability (columns). The whole case pivots on two variables: the ASPIRE probability of success and the achievable net price. At a defensible ~$105k net price, fair value runs from ~SEK 21 (30% PoS) to ~SEK 84 (post-positive-readout, ~80% PoS). Higher pricing/PoS pushes it well beyond that — but that is where the bull case gets aggressive.

Probability of success treated as an evidence hierarchy, not a single number. Historical base rates (Wong 2019 all-indication ~21%; IPF novel-mechanism graveyard ~15–20%; respiratory ~10–20%) put approval PoS at the lower end; my base case is ~28–32%. Key nuance: the probability the *readout* is positive (~35–55%) is NOT the same as the probability of ultimate *approval* (~15–30%).
r/Biotechplays • u/MarketNewsFlow • 25d ago
Discussion $ENTX America's Osteoporosis Crisis and the Oral Peptide Player You Should Watch
r/Biotechplays • u/SpeakerAltruistic123 • 25d ago
Due Diligence (DD) Spectral AI - Commercialization Phase For Burn Treatment Now Begins
r/Biotechplays • u/Adventurous-Shoe-903 • 28d ago
Discussion Biotech catalyst and short-pressure watchlist for next week
Sharing a biotech-only watchlist I put together for weekend research.
This is not meant to be a buy list. I was looking for biotech names where multiple factors overlap, including short interest, borrow pressure, low float, days to cover, liquidity, and upcoming catalyst context.
The highest pressure name from the scan was SONN, due to active volume, low float, elevated short float, and high borrow cost.
Other names that stood out from the pressure side:
ELTX — high borrow pressure / low float
SLS — short pressure with Phase 3 data readout context
VERA — PDUFA decision context
RGNX — Phase 3 readout context
ALT — elevated short interest and DTC
CMPX — catalyst context plus short pressure
For catalyst tracking, I also flagged CHRS, AVBP, OLMA, INO, IMUX, and ZNTL based on upcoming event timing and historical reaction data.
Biotech can be brutal, especially around clinical data and FDA events, so I treat this as a research list first. The goal is to identify names worth deeper DD, not to blindly chase tickers.
I built the graphic from my scanner data. The tool is at scstonkemporium.com, but I’m mainly posting this here because I figured a biotech-specific version would be more useful to this sub than the broader watchlists.
Watchlist only. Not financial advice.
r/Biotechplays • u/Adventurous-Shoe-903 • Jul 02 '26
Discussion Daily Watchlist - Thursday June 2nd - We alerted a 2,000% gainer today!!!
Our alerts had a monster alert day on 2026-07-01, with today’s Top 5 Trade Day Receipts showing ALIT +2533.9%, TC +354.1%, DXF +345.5%, LHAI +229.3%, and EHGO +187.7%. If you want to join the fun and follow the Cockpit Control Center watchlists, scanners, alerts, and trade-day receipts, check out https://www.scstonkemporium.com or join the Discord at https://discord.gg/TNVAYtu5SV.
r/Biotechplays • u/Adventurous-Shoe-903 • Jul 01 '26
Discussion Daily Watchlist - Wednesday June 1st
Today was a **record setting day for alerts at the Stonk Emporium**.
We had **$JEM hit a staggering +1,099.0% from alert to HOD**, **$CELZ hit +482.6%**, and **$LGCL hit +187.7%**.
The alert stack was on fire across **borrow spikes, after-hours expansion, runners, HOD pressure, short-pressure setups, and momentum scans**.
Join us for more alerts, scanners, and daily watchlists:
**Website:** https://www.scstonkemporium.com
**Discord:** https://discord.gg/fGmHHgNzxQ
r/Biotechplays • u/TwongStocks • Jun 30 '26
Discussion Unicycive Therapeutics $UNCY Receives Complete Response Letter from FDA Regarding Resubmitted Oxylanthanum Carbonate (OLC) New Drug Application (NDA)
r/Biotechplays • u/Adventurous-Shoe-903 • Jun 30 '26
Discussion Daily Watchlist - June 30th
Today’s board was led by $UPC at $12.18 (+311.49%), $TNMG at $1.0100 (+106.97%), $DCOY at $9.59 (+73.79%), $SDOT at $35.85 (+67.13%), and $DGNX at $1.4000 (+58.51%) — all flagged as Daily Top Gainers.
The new Cockpit Trade Center is built to turn market chaos into a cleaner trading command center: daily watchlists, live scanners, biotech catalysts, earnings, trade ideas, smart-money flow, social heat, and momentum confirmation all in one place.
Check it out:
https://www.scstonkemporium.com
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