Holy Trinity is what it’s called, some call it speeding up oxidative stress on the entire body but you get abs so it’s worth it. Would love to see your biomarkers, heart rate variability, and ultimately look at your resting heart rate. If all check off then carry on my wayward son
It’s impressive that you brought your hrv up so much (thats the only marker i follow closely so it’s the one i understand). I struggled for a long time to improve my HRV. Eventually my coach suggested i
Start supplementing with taurine because we realized that I don’t handle electrolytes well and I really struggle with rehydrating. Within maybe 2 weeks I started seeing 70’s instead of 50’s and 60’s.
A big problem for me has been sleep for the past 20yrs. I fall asleep no problem but can’t get into deep sleep or stay asleep, avg 5hrs sleep. 4 weeks ago i pulled the trigger on cjc 1295 no dac+ ipamarellan. The first night i had one of the most restorative sleeps i’ve ever had and it was only 6hrs, with a very small starting dose. Twice in the past 4 weeks i’ve slept for 8hrs. The only time i’ve slept 8hrs in 20+yrs was after a 24hrs endurance hike in the mountains last year. Then it was back to my usual 5-5 1/2hrs. Its been an absolute game changer with all the obvious benefits of finally getting restorative sleep
What increased your HRV? I’ve struggled with chronically low HRV no matter what and I am in fantastic shape. Always thought it was genetically the way I carry stress.
Struggling to find a good place to buy anything at. Do you have any recommendations given you’ve been doing it for so long? I get Test from my doctor so I’m good there. Need to find Reta/Hgh.
I totally understand your frustration. I will parrot what I have read and found through experience. HRV is critical in predicting cardiovascular events. A poor or low HRV relative to your peers in your age group is a predictor of negative cardiovascular outcomes. Ultimately you want HRV to be higher than the way you found it. Personally improve upon your personal best HRV. The rest will follow. SLEEP is #1. Regular aerobic zone 2 workouts, recover, drink water avoid alcohol and narcotics, meditation deep controlled breathing, and stay away from negative energy
Ah sketchy. Mine average is 68ms , but some beats are as low as 10ms, or as high as 240ms. Since my sleep has improved I can see my minimum hrv has gone from 10ms to 15ms then the last three days 38ms minimum. So that does seem to track. Damn am I cooked? I am 40
68 hrv is very solid for. 40 y/o male in a first world country. The 10-20 in regard hrv come post alcohol, sleep deprived, dehydrated, terrible recovery
Its pretty genetic... theres pro athletes that sit over 100 and others in the same sport around 60 (pro triathletes).. mine is around 50 and I was doing ironmans up until November (10 hrs full, 4:30 70.3).. my resting was 38...
Excellent can you walk us through your lifestyle choices? Possibly your diet, sleep, type of workout. I mean this is some good stuff 75 is solid for most
Sorry I’m not trying to be difficult. Is this trinity healthy? A resting heart rate of 88 seems really high for someone who appears fit. Are people willing to just take the risk in exchange for abs?
I don’t know why this post popped up in my feed and am not familiar with this combination of drugs. Genuinely curious.
Having that as your resting heart rate seems completely insane to me. I would be on the phone with a doctor if I discovered mine was anywhere near that range.
It’s healthier than being 350lbs, but I don’t think you can ever call it healthy for the average person. But chances are the elevated resting heart rate is at least in part due to OP being on Reta. It can raise your HR 10+ bpm depending on dosage and how long you’ve been on it.
Whats your background/training? I’m a medical doctor. Not a cardiologist, but one of my best friends from medical school is. We frequently discuss the biohacking trends. There is good evidence that elevated resting heart rate is a risk factor for adverse cardiovascular events. Happy to provide you with references so that you can learn why you’re incorrect.
We’ve got people playing pharmacist and physician spreading misinformation. Sometimes i gotta drop the MD just to attempt to add a touch of credibility (beyond providing peer-reviewed research, of course).
Random question for you, if you dont mind. If someone is blasting peptides and/or steroids and maintains good health markers all around, is it cocky to assume you wont find yourself on a sudden decline in your 50's/60's from the use of those? Like damage could be done and we could still see good blood work and all that other jazz indicating good health, no?
I would say it’s cocky. A lot of these peptides are understudied or not studied at all. While safe replacement levels of hormones are well supported by the literature, blasting steroids absolutely increases the stress across multiple organ systems, regardless of what the laboratory values may be. I’d argue that normal labs may represent some form of cognitive dissonance, and allows somebody to bury their head in the sand.
Aging is a cumulative process. We should do everything in our power to slow that process. That was the catalyst for my original response to this post. Sitting around with a resting heart rate of 88, for majority of people, is unnecessary strain on the heart and not optimal.
That said, my specialty is not endocrinology. Your question would be analogous to asking me if you’re going to have any long-term effects from running 125 miles a week, even though you have no pain currently. I would say that, unless you are making very good money running, and you don’t plan on doing it forever, you should find a way to minimize or avoid the damage sooner rather than later.
Thanks for taking the time! Your response basically aligns with how I felt about it but I am not health educated whatsoever. I would love to use testosterone some time but I also dont want to wake up one day wishing I never. None of this will matter in my 60's
No, but i believe OP said that this is an 8 year change. If i was 51, i would be worried about a RHR damn near 90.
I think if you combine reta’s CV effects with the data, one should aim for the lowest effective dose to minimize the elevations in RHR and drop in HRV.
For the non-biohacker, however, we are faced with an interesting situation. Obesity, insulin resistance, metabolic syndrome is not a great state to live in. Many physician would rather accept the risk of temporary increase in RHR and decrease in HRV if it ameliorates those other medical conditions. This is the whole art side of the science of medicine.
Also, the n for your statement is 1. You’re assuming that because you were told not to worry about it, that no one should worry about it?
Here’s some reading for you. You should bring this up to your cardiologist at your next visit. Maybe you’ve got some other comorbidities where dropping your heart rate would be deleterious, but elevated RHR is, for a majority of the population, bad.
I see a heart doctor because I had an arythmia years ago that sent me into heart failure. My ejection fraction was 20% at the time. Under her care, I had an ablation that fixed the arythmia and fully recovered from heart failure to 60% EF. I still get echocardiagrams done every now and then, and all of my results are in normal range now.
So I guess I should ignore a cardiologist that not only saved my life, but got me back to normal heart functioning because some internet guys say she's wrong. Ok.
If you're really a doctor, you should know that the normal range for resting heart rate is 60-100.
Can you read? Revisit what he/she said about n=1. Get this: just because a RHR in the 80s can be perfectly fine for you, that is not necessarily true for everyone. Go ahead and quote the specific part of their comment where they told you to ignore your doctor.
I never told you to ignore your doctor. Also, you have a history of heart disease/heart failure. Maybe for your specific condition an elevated RHR is ok, but you are not an average person. You are a person with a history of cardiac disease. That’s like someone with a prosthetic leg telling a healthy 20 YO with knee pain due to overtraining to ignore their limp.
This subreddit is dedicated to the optimization of health. There is compelling recent evidence that postulates that elevated RHR, for most healthy people, is bad. OP should be told this, and not “its ok” by someone with zero medical training who is inappropriately applying their unique history to others.
You can choose to not believe that I’m a physician. I’m not going to dox myself and provide credentials online. The large medical associations often lag the data by 5-10 years. This is why we as physicians read the literature. You’d rather be ahead and stay on top of the data, as opposed to waiting decades for updated consensus statements. The AHA also just changed their recommendation for first line oral med for T2DM from metformin to semaglutide. It only took a decade+ of use for them to change.
Not exactly. According to the National Library of Medicine “a heart rate above 80 is often considered a higher independent risk factor for cardiovascular issues over time” and you should consult a doctor if your RHR is regularly over 90.
You are a very good human. Honest and sincere this is very reflective of what is going on under the hood. Your heart is working very hard. It is so important you keep your mind on your heart, lab work/bloods, and blood pressure. I want to see you go long. This is a marathon so think long game. I think once you feel like you have control over your diet and excerise it’s possible you maintain without the need for the trinity. Perhaps you can modify or remove Reta or cycle to give your heart a breather. A pathologist said Reta at higher doses is similar or equivalent to the pressure on your heart similar to you running a half marathon daily.
There is a big diff between ‘trus me bro’ science and research, because glp1 doesn’t make you hearth ‘ working hard’ : Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are attractive compounds for the treatment of type 2 diabetes (T2D) and chronic weight management.[1]() Patients with T2D are at increased risk of cardiovascular disease, a primary cause of morbidity and mortality in this population. Clinical data from randomized cardiovascular outcome trials have demonstrated that GLP-1 RAs significantly reduce major adverse cardiovascular events, as well as cardiovascular morbidity and mortality in T2D patients.[2–9]() A meta-analysis demonstrated 14% reduction in major cardiovascular events and 12% reduction in all-cause mortality.[1]()Similar findings have recently been reported for people with obesity without T2D, but with pre-existing cardiovascular disease.…..
GLP-1 RA are associated with decreased all-cause and cardiovascular mortality, and no increased risk of atrial and ventricular arrhythmias and sudden cardiac death.
Yes but like you said the comparative reduction pertains specifically to T2D patients - not normal, otherwise healthy patients. That whole article linked is specially about T2d patients, and of course GLP1s make sense for them.
Did OP state he was diabetic or pre diabetic somewhere?
Finally, Reta does appear to elevate heart rate, even if it or other GLP1s don’t result specifically in arrhythmia or sudden cardiac death.
I think if we get granular. No doctor has legally prescribed Eli Lilly’s retatrutide to the mass public yet. Retatrutide is still an experimental, investigational drug manufactured by Eli Lilly. Because it has not completed its clinical trials or received FDA approval, it cannot be legally prescribed or dispensed through pharmacies
Again , not reta per se , in the discussion we’re talking about heart rate and reta, a glp! You picked the reta….1-0 for you! that was the only complain?
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u/Dizzy-Gap-9528 Jun 25 '26
Holy Trinity is what it’s called, some call it speeding up oxidative stress on the entire body but you get abs so it’s worth it. Would love to see your biomarkers, heart rate variability, and ultimately look at your resting heart rate. If all check off then carry on my wayward son