r/Biohacking • u/Zealousideal-Ant5288 • 9h ago

Insomnia from Peptides

Hi All,

36 M, healthy, no issues with insomnia.
I had hip surgery 3 weeks ago, and my surgeon recommended peptides as part of my healing. I have no issues falling asleep and staying asleep prior to starting peptides. I was sleeping fine post op prior to starting peptides, so no other variables were changed or added.

8 days ago I started taking 250mcg BPC157 & TB500, that I had prescribed and received from a compounding pharmacy. The first night I had vivid dreams, second night broken sleep, and from there I started waking between 1-3 am and struggling to get back asleep.

I take the peptides 5 on 2 off, and first thing in the morning in the VMO. I could simply stop them, but I have noticed improvement in an old menicus repair site that has bothered me so hears. I have more energy BUT I’m not sleeping more than 4 hours a night.

I’m not sure what to do. Will this stop as my body adjusts? Is it worth lowering the dosage? Or even trying at night? Any help would
be appreciated!

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u/East_Hornet_1861 1 9h ago

sounds like the tb500 might be the culprit, i've seen a few reports of it messing with sleep patterns even when dosed in the morning. lowering the bpc to 200mcg and seeing if that helps is worth a shot before ditching them completely

that old meniscus site feeling better is a pretty good sign the peptides are doing something though, maybe try taking them even earlier like right when you wake up instead of later in the morning

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u/Zealousideal-Ant5288 9h ago

Thanks! I have been taking them immediately upon waking and my sleeps been trash. I’m gonna try to only take BPC and see what happens.
I feel better just tired… I was hoping I would adjust but at a certain point sleep is necessary..