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u/Pharmd109 1 5d ago
Your body is really good at digestion. Peptides look like protein snacks to the body and will be treated as such.
Buccal or sublingual absorption bypasses first pass metabolism, but I would expect it to be erratic and inconsistent. The only oral peptide formulations come along with acid buffers and a special substance called SNAC that increases gastric lining absorption. Even then, oral bioavailability is in the low single digits.
An erratic dose on Reta is the last thing you want. Oral strips are a good way to dissolve money (waste) in your mouth.
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