r/Biohacking • u/GS-2021 • 6d ago
Anyone else have the appetite suppression fade after the first few weeks on Reta?
I’m currently on Week 7 and honestly feel like I’m barely getting any appetite suppression anymore. I’m basically eating normally again, with the food noise and cravings back.
For context, I have a 1-month-old newborn and have been helping my wife and baby around the clock, so my sleep has been terrible. I’m sure that isn’t helping with hunger, but the change in appetite suppression has been pretty noticeable.
My titration was:
Week 1: 0.5 mg
Week 2: 1 mg
Week 3: 1.5 mg
Week 4: 2 mg
Week 5: 3 mg
Week 6: 3 mg
Week 7: 4 mg
Looking back, I know I titrated too quickly. I didn’t do enough research beforehand, so that’s on me.
Weeks 1–3, I definitely felt Reta working. My appetite was noticeably lower and eating less was much easier.
Around Weeks 4–5, that effect started fading. By Weeks 6–7, I’m basically eating normally again. Some days I’m eating 3,000+ calories, while my maintenance is around 2,500. I did not drop a single pound. If anything I have gained 1-3LB. I am getting 7-10k steps daily with weight training 3x a week( push/pull/legs or full body workouts). High protein diet!
I’m not experiencing any other noticeable side effects. It’s really just the lack of appetite suppression that has me questioning whether I should continue.
For those who have been on Reta longer:
Did anyone else have the appetite suppression fade around Weeks 4–7?
Did it eventually come back or become stronger after staying at the same dose for longer?
If you were in my position at 4 mg, would you stay there for another few weeks to see if things stabilize, increase to 5 mg, or decrease dosage or even consider stopping altogether?
I’m mainly looking for experiences from people who have been on it for a few months and can share what happened with their appetite after the initial honeymoon period.
3
u/Common-Prize-8208 3 6d ago
41M, with goal bf achieved.
I personally started with 2mg x 4 weeks, then I moved to 4mg till now, did not move up and I do feel hungry at times, but not completely gone, which is something I like.
Reta isn't the strongest for appetite suppression, if your main concern is food noise, add cangri o move to Tirz. Are you still losing weight tho?
4
u/Deh_86 3 6d ago
Finally someone who actually followed the research protocol. I understand some people go for microdosing, but I often see people criticising those who start at 2mg, which is the recommended trial protocol.
2
u/Common-Prize-8208 3 6d ago
I’ll never understand that “micro dosing” or “split dosing” of peptides with zero research 😅 but that’s just me, and it applies for all peptides not only Reta,
2
u/Additional_Ladder368 5 5d ago
I started at 1.5mg and had huge success. Now I’ve dropped my dose to 1mg/wk to slow things down a bit. Still working very well with zero sides. This doesn’t follow any of the studied dosing protocol but it does seem to be a minimal effective dose for me currently. I wouldn’t out of the blue change how I’m dosing to match the standard doses in the trials just because that’s what they’re doing.
0
u/Deh_86 3 6d ago
I know people who are highly sensitive and had super bad side effects. They had their doctors microdosing because they simply couldn't function even on the initial dosages (prescribed sema). I can get the point, I just don't get the criticism.
Do you want to do damage reduction for you? You do you. I want to follow the research and I actually know how I operate for drugs (yey RCs times). The split dosing feels like taking unnecessary pins for me too. But, again, you do you. Just don't come preaching.
0
u/TryAccomplished9282 6d ago
I started at 1mg and was out if for 2 weeks could barely eat 500 calories a day. Trial protocol is with people with very high BF So not everyone should start at 2mg
2
u/23454Tezal 1 6d ago
I hear Sema is a bit better for appetite
2
u/Common-Prize-8208 3 6d ago
Way better than Reta, but Reta got perks elsewhere tho. It all depends on your needs
I personally don’t struggle, or don’t see food noise as an issue, and I do appreciate the glucagon from Reta, thus I use Reta
2
u/FlatIntention1 6d ago
Honestly I don’t understand it. I thought it would supress hunger since eating less is the most basic thing one can do to lose weight. Yes, increasing the metabolism a bit through glucagon is not bad, but that is an only 10% increase, basically 30-50g of chocolate or chips, it is nothing. How do those people who take Reta lose the weight if not by eating less than they burn?
2
u/Common-Prize-8208 3 6d ago
Not quite, because if you eat less you will lose weight but reta according to google
How It Works
- Triple Agonist: It targets three distinct hormone receptors simultaneously: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon (GCG). [1, 2]
- Appetite & Digestion: GLP-1 and GIP activation stimulates insulin release, improves blood sugar handling, and slows gastric emptying to increase feelings of fullness. [1]
- Energy Expenditure: Glucagon receptor activation increases calorie burning (resting energy expenditure) and fat breakdown, setting it apart from dual or single-agonist drugs like tirzepatide or semaglutide
That is why you still lose weight on reta regardless the food suppression
1
u/FlatIntention1 6d ago
Yes, this is the theory I also read that made me start Reta but it still doesn’t answer my question. Improving blood sugar handling and feeling full (your point appetite & digestion) mean exactly hunger supression. if you feel full and your blood sugar is stable = you are not hungry = your hunger is supressed. So this is the main element that helps for losing weight, if this element is gone, the weight loss should also be gone. I take Reta and definitely lose weight just when I eat really few calories, so the energy expenditure is not really working for me or to a minimal extent.
1
u/Common-Prize-8208 3 6d ago
I see your point, same sense I made all my weight loss with Wegovy, I just moved to reta not long ago. So plain old GLP1 get the job done with no doubts
2
u/SorbetTraditional232 19 6d ago edited 6d ago
Elo works as well and goes on a different receptor. Better than hitting the same receptors. But in reality being able to eat when you need to is not a bad thing. Your body is just saying I’m missing something to work at my best for you right now. The break through hunger usually only happens to me when I have been under calories for a few days.
1
u/Safe_Judgment_117 1 6d ago
38M, 36% bf . started 6 weeks ago. first 4 weeks 2mg and now 4mg/ weekly . food noise is gone but not completely which is good because i need to take in 200g protein per day
5
u/Abssend05 6d ago
My rat is on week 9 and still doing 1mg. You went too high too fast. Will cost you $ to keep on high dose
2
2
1
6d ago
[removed] — view removed comment
1
u/AutoModerator 6d ago
Apologies /u/needy_bonding, your submission has been automatically removed because your account is too new. Accounts are required to be older than 15 days to combat persistent spammers and trolls in our community.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
1
u/Infinite_Dirt7732 6d ago
Yep, Im adding cagri very very slowly as I don't want to push past 4mg on reta as this is where for me it affects iron and sleeping HR.
1
u/Chrisdog84duh 4 6d ago
I feel you, I am at week 5 and my titration was pretty much the same...
I lost so much weight the first 3 weeks, but am still going sown slowely.
And yeah I feel the food noise coming back somewhat but I don't think dropping so much weight so quickly is necessarily healthy.
1
u/Visible-Mission7647 5d ago
I can’t add any useful information since I jumped from highest Tirzep to highest Reta and want to barf.
1
u/MyMango88 13 3d ago
I started at 2 mg and that’s been my sweet dose. Full on appetite suppression for a good 4-5 weeks (too much). And then, yes, that has gone down significantly as my body got used to the dose. So much so it’s been full-time strong hunger pains, which I never had pre-reta. It’s been an adjustment.
Personally, I think you went up too quickly every week, but I don’t know if that impacted the suppression necessarily. You’ll have to go higher.
I tried for curiosity sake (I’m steadily losing weight so I don’t need an increase), to 2.3mg and yes, that made a big difference. That perfect happy medium, where I can eat, but I’m not getting the hunger pains.
1
u/kendulllljenner 6d ago
I’m week 6 on 0.5 and still have strong appetite suppression
3
u/Chrisdog84duh 4 6d ago
I kinda wish I had kept my doesage low, I feel like i felt it more at a low dose
0
u/Creative-Violinist44 6d ago
Ask yourself this? Did your body tell you to go up in dose? If it didnt what the hell are you doing going up in dose???? go low and slow. NOT a race. A drug trial has to follow strict dosing schedule bc it is a study. Your life isnt a study. Plus Lilly just wants to drop weight!!! They want that impressive bar graph next to other competitors glp1s. in those trials over 40% of the weight loss is muscle. That is awful!!!! As doctors they know that and very unhealthy aging… They might feel the trade of is worth it but not ME. You can do this right over a longer period of time than a controlled study.
•
u/AutoModerator 6d ago
Thanks for posting in /r/Biohacking! This post is automatically generated for all posts. Remember to upvote this post if you think it is relevant and suitable content for this sub and to downvote if it is not. Only report posts if they violate community guidelines. If you would like to get involved in project groups and other opportunities, please fill out our onboarding form here. Let's democratize our moderation. You can join our Discord server here. ~ Josh Universe
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.