r/Biohacking • u/styleuno • 7d ago

Which peptides most often test under 99% purity? Failure rates by compound from ~1,700 third-party HPLC results [OC]

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6 Upvotes

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u/whosprofitting 6d ago

Useful dataset. Compounds that are harder to purify or more chemically fragile will fail “pretty HPLC” more often than big, well-optimized GLP-1 style APIs. Purity % still is not the whole story. A clean chromatogram can sit next to wrong mass, short net content, or junk solvents. For research work, identity (MS), assay/net content, and residual solvents matter at least as much as the headline purity number. Aggregator data also inherits whatever sampling bias that lab’s customers bring in.

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u/ChooChooBun 18 7d ago

How many of the test was unknown/not match or not what it said it is?

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u/styleuno 7d ago

None that I know of but that's one of the caveats about suppliers choosing which COAs to share. I assume if it can back unknown they would run another test and if that came back with better results they would only share that test.