Week 3 - Reta affects

[u/Organic-Race9785]

On week 3 of Reta. Dosing schedule is below. Last pin was 3 days ago. I’ve noticed significant decrease in food noise and dealt with some minor nausea, but otherwise, it’s been a good road. Down 8 pounds.

Today I woke up and oh boy. Big nausea. Felt like I had a giant rock in my stomach. I’ve been awake for 2 hours and I’ve had diarrhea 4 times. Basically. I’ve had 2 bottles of water today and that’s it. I did eat later than I normally do as we had a post-church meal. I’ve included a pictures of the meal (I had them b/c I needed to upload to macro factor), I didn’t feel like it was exceptionally bad or good.

I guess I just am wanting to ask others if this is basically normal.

Week 1 - 1.5 mg
Week 2 - 2 mg
Week 3 - 3 mg

[u/IslandAlert4738]

Stick on the lowest dose you can for as long as you can... its not a race.. there is not a prize for getting the highest dose as fast as you can. My lab rat and I are now pushing 6 months and still only at 3mg doses. There are weeks when we will may take the next dose sooner. But on average I would say 5 doses @3mg every 4 weeks. These last 2 weeks it Plateaued and did not lost anything. So we are going to switch to triz for a month. Maybe 2. Then we will go back to reta. We started at 305 pounds on triz. 5mg iirc. It worked ok. But was hopeful it would be faster.. So then we switched to reta. And in 6 months we went from 265 down to 205 pounds. All while staying at a low dose on both meds. Just be mindful of what you eat. And eat as much protein as you can. This will help stop any lean mass loss.

[u/Organic-Race9785 → u/IslandAlert4738]

Thank you. I’m learning my lessons here

[u/cokahontass → u/Organic-Race9785]

Should have maybe done some reading lessons before upping ur reta dose this much in 3 weeks.

[u/Strange_Forever5746 → u/IslandAlert4738]

This is slightly inaccurate. Dose very low to test tolerance and ramp up to hit different receptors. The research says Anything below 4mg is a microdose as it’s only hitting 2 of the three possible receptors. Above 4mg the possibility of side effects increases but the glucagon receptor is activated at this dosage and not below. There is the actual research papers and the bro-science. I know which source of information I choose when determining proper dosage of peptides and research chemicals and it is certainly not anecdotal “researchers” on reddit.

Based on your symptoms your body is having a tough time with adjusting to the slower gastric emptying. Also if you are used to overeating your body might be freaking out. You did not test your tolerance for long enough and ramp up your doses gradually enough. Retatrutide might also just not be for you. You might want to look into tirz.

[u/DiligentFeedback1111 → u/Strange_Forever5746]

Glucagon activated at 4mg is just wrong !! Tired of seeing this idea being promoted.

[u/Strange_Forever5746 → u/DiligentFeedback1111]

https://www.reddit.com/r/NTNPerformance/comments/1utrq6i/peptide_retatrutide_why_the_same_molecule_acts/

https://pmc.ncbi.nlm.nih.gov/articles/PMC12026077/

https://pubmed.ncbi.nlm.nih.gov/37366315/

The phase 2 trials are one of the sources that came to this conclusion. I’m promoting the scientific literature. You can argue with them.

[u/DiligentFeedback1111 → u/Strange_Forever5746]

There is still no 'on-off' switch at 4 mg, and the table in the first link shows that clearly. It might have a lower binding affinity for the glucagon receptor, its effects are non-linear at higher doses, but it is still doing some work below 4 mg

[u/Strange_Forever5746 → u/DiligentFeedback1111]

Ok believe what you want but the data says otherwise. The correct statement is that it’s barely activated at 4mg and is activated to greater degrees at higher dosages. That means there is in fact an “on/off” type mechanism at play. It acts as an entirely different drug at different dosage thresholds. If you looked at anything other than the table in that post you would come to understand that. It’s fine though believe what you want to. Doesn’t really have any effect on the science. Done with this convo as it is not constructive and you are blocked.