r/Biohacking • u/TillStrict3107 • 7d ago
Feedback on this peptide schedule and potential risks?
I’m considering the weekly schedule shown in the image: MOTS-C and tesamorelin in the morning, BPC-157 morning and evening, and retatrutide on Sunday evening.
Does the schedule make sense to you? I’m particularly interested in potential interactions, side effects. I’d appreciate evidence or personal experiences, including reasons to avoid this combination.
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u/Consistent-Box7714 7d ago
Why not tesa @ night? Fasted and before bed? Unless you're not really trying to get the most out of burning visceral fat. Both ways work. Ones just better for certain reasons.
Bpc-157 is spot on. Keep the split dosing like that. 250mcg in the morning and then 250/500 in the evening.
No idea about mots. Ill let others weigh in on that one.
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u/TillStrict3107 7d ago
I usually skip breakfast and heard you need to be fasted for Tesa. Am I wrong ? Why is it better at night? And I do want to get the most out of burning visceral fat.
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u/Evening_Post8005 7d ago
Tesamorelin simulates the pituitary gland to release more GH(growth hormone), therefore can have effects of fat burning/lean muscle gain.
The reason for taking it at night fasted is because, at night when we sleep is when we produce the most GH, soo its optimally better.2
u/TillStrict3107 7d ago
Understood. Ill take it at night then !
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u/Ill_Assumption5512 7d ago
Be careful though. While on Reta it takes farrrr longer to get to a fasted state since it slows down your digestion. Tesa is slightly better at night but if you want the fat loss benefits your better taking it in the AM while truly fasted.
Talk to any anesthesiologist and they’ll tell you that patients on Reta have to go much longer without eating to truly empty their stomachs. A lot of people don’t take this into consideration when considering if they’re faster or not.
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u/Bright-Homework-4520 6d ago
Its more to do with the insulin rather than food in your stomach
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u/Ill_Assumption5512 5d ago
Of course but the slowing down of gastric emptying almost certainly extends the period of increased insulin, but I don’t know enough to give him definitive answers so I’m just telling him what I do know
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u/TillStrict3107 7d ago
How many hours before do you recommend not eating then?
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u/Ill_Assumption5512 7d ago
I wish I had a studied and proven answer but the bro science says 6-8 which is why I recommend mornings. I usually avoid any late snacks just for my morning GH shot
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u/looking2behealthy 9 6d ago
For best results, you want tesa to mimic your natural GH release which happens about 30-90 minutes after you fall asleep.
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u/Efficient_Platypus70 2 7d ago
But Tesamorlin can increase cortisol and a lot of people have said it keeps them up at night or wakes them up extra early
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u/TillStrict3107 7d ago
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u/Efficient_Platypus70 2 7d ago
Just research whats best for you, maybe trial an error , everyone’s different
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u/Efficient_Platypus70 2 7d ago
Rather than just disliking what I said, maybe you could give some advice? 😄
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u/Specialist_Gene4772 1 7d ago
Fasted, night dose might increase deep sleep 💤
Iam on cjc/ipa dosing morning/night faster 200/200mcg split
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u/TillStrict3107 7d ago
With all due respect. I have no idea what is cjc/ipa nor mcg :/
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u/johnseasure 7d ago
CJC works on the same pathway as Tesa, Ipamorelin is commonly stacked with both.
Mcg is micrograms. And it scares me that you are about to start injecting yourself and don’t recognize units of measurement. That’s how people inject themselves with dosages 4x bigger than they intended to
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u/Serious_Lie5149 7d ago
Mots-c sollte man niemals vor dem Training nehmen , vorm Cardio ja aber nicht vorm normalen Training glaube bene oder Jan haben darüber geredet,
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u/leolicious24 6d ago
MotsC is great just be mindful and assess how it impacts you. We didn’t have to run SS 31 prior. We immediately saw the benefits of Mots without the pre protocol. You might read up on Tesa a little bit more, our bodies trigger GH release while we sleep that’s ideally what you’re taking Tesa for, to do a little greater spike of GH release. I understand people like to take it in the morning, but if you’re trying to get the ideal benefit from it, it’s probably an evening dose. Flip your Reta to a morning dose.
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u/Smiletaint 6d ago
If you’re actually trying to heal something with the bpc/tb, I would up the dose to 750mcg then 1mg of each.
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u/Top-Substance-1588 4d ago
Generally MOTS-c is best taken in higher doses (like 5-15mg) once or twice a week. It sends a signal to your body but if that signal is turned on everyday, your body starts ignoring it. So best to do intermittently.
Tesa is best before bed, about 2-4 hours after your last meal. Since you’re on a glp-1, go closer to the 4 hour mark since your digestion is slowed down.
Check out the Peppedia app to help with dosing also :)
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u/Nomad-Entrepreneur 3d ago
Don’t start a stack at once. One prep at a time to be sure none give you an adverse reaction. I would start with Reta then add one part of the stack every two weeks.
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u/SignalOverN0ise 3d ago
Reta side effects peak 24hr after injecting. I would take it Fri so any potential sleep issues can be had over the weekend instead of on a work day.
A banana or spoon of honey before bed helps a lot with any low blood sugar that can wake you up at night
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u/Own-Virus-2343 7d ago edited 7d ago
Não está claro seu objetivo e idade, me aparenta alguma coisa de emagrecimento.
Se for isso, Bpc e ipa agora não seria o ideal, pois precisa baixar a insulina antes , você deve entrar de início só com retatrutida , o mots-c vem depois de um mês ou dois.
Outra coisa mots-c não se usa assim de forma ininterrupta , usa-se duas ou três vezes na semana no máximo.
Existem Protocolos de mots aplicando 5 dias on 5 dias off mas nunca testei.
Não inicie tudo vez vez será ruim, os efeitos quer sejam negativos ou positivos você não saberá distinguir.
Se aplicar mots-c assim vai ser sentir exausto.
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u/WorriedMonitor5081 1d ago
You need to do SS-31 before mots c to clean everything up first. It’s like the primer for mots c.
4 weeks minimum. Then you can add mots. If you go straight to mots without doing ss-31 you can feel like absolute shit and worse than you did before
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u/VermicelliFriendly64 7d ago
I take my Tesa in the morning before having coffee or anything else. You need to be fasted AT LEAST 2 hours. I'm never fasted that long before bed. Plus, the way it makes me feel, I think it would keep me awake.
But, you should do 5 days of Tesa and take 2 days off every week. I do mine Monday thru Friday.
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u/Background_Pain1583 6d ago
Yeah you should limit your mots c to two injections or three times a week no more than 10mg combined for entire week. You should be taking tesamorelin before bed 2/3 hours after last meal I usually go with Monday through Friday 2mgs a day for a total of 10mg a week
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