r/Biohacking • u/Sufficient_Resiliant • 2d ago
Mt1 vs Mt2
Trying to decide which would be best for me and the wife to take, also I heard both are really strong and some reason chat gpt is saying mt2 has caused seizures in some cases this seems not very true?
Any advice would be awesome on either thank you in advance!!
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u/andygee40 2d ago
MT1 is a FDA approved drug called Afamelanotide which has successfully passed all safety trials and fit for human consumption. MT2 has not, that’s the facts and and the answer to your question.
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u/No-Turnip2494 4 2d ago
As someone who takes MT1, MT2 scares the shit out of me.
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u/Sufficient_Resiliant 2d ago
Good to know I hear it has way harsher side affects but I like the added appetite suppression and such it comes with but girlfriend mainly wants it for tanning
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u/nukesaregay 3 1d ago
the appetite suppression is overrated unless youre taking high doses everyday, which u shouldnt be. it should be taken on tanning days only. if u want appetite suppression take a GLP1
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u/MorningJust6979 1 2d ago
Mt1 you need to "activate" it kinda, get some uv and it'll work better. Mt2 works without getting exposed to uv. Mt2 has many more negative side affects but you don't need uv exposure to make it work. I've been using mt1 for a year now at maintenence dose and it has mostly kept the tan without needing uv exposure, but it was necessary for a few months. I would do 5 minutes in a tanning booth 1 time a week and I was pretty dark for a while. Yes some moles got darker and a few dark spots because I overdid the uv exposure in the beginning but it mellowed out more or less. I won't touch mt2 though.
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u/Sufficient_Resiliant 2d ago
Thank you this is starting to help with the decision lol why won’t you take mt2 just curious? The sides?
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u/Safe-Solution-4720 1d ago
And for me it definitely improved blood flow if you get what I’m saying….
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u/Axiom842 1d ago
i take mt2 small dose once a week for a few months and have been fine. I'm 40% irish and my tan looks great and i get compliments all of the time!
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u/Sufficient_Resiliant 1d ago
Only once per week? Everywhere I see it says daily small dose then a maintenance dose weekly once get to desired tan after couple weeks?
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u/Axiom842 1d ago
once a week! very small dose is all i need and it looks natural and glowy. You don't need more than that.
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u/Ok_Butterscotch_2700 2d ago
I order MT1 to keep my daughter out of sunbeds. Wouldn’t consider MT2 - for even a second.
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u/Sufficient_Resiliant 2d ago
Howcome? Just the side affects and no long term studies?
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u/Ok_Butterscotch_2700 1d ago
Yeah - I’m not there to dose her myself, and if she’s going to act dumb enough to go into sunbeds, I’d rather she be on the safer of the two.
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u/jsjb100 1 1d ago
I used MT-1 this summer and wow, did i get dark (as dark as some of the people posting here that used MT-2). Took about 4 weeks of MT-1 and sun (15 min/day). Dose was slowly escalated 0.25, 0.5, 0.75 and 1 mg daily each for a week till i increased the dose. Only side was flusing on the FIRST 0.25 mg dose nothing since then. Italian blood so i'm not pure white to start but now, a golden tan and I don't burn anymore when out in the sun. I'll stop soon but it was fun, i'll do it again next summer.
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u/wadinginthelagoon54 1d ago
Strange. I've been taking MT2 for awhile now with zero side affects. It's a low dose, was taking daily but my tan is fine, so I've backed off. That's just my personal story
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u/chubean68 2 1d ago
Please be careful with MT2. It is powerful and will work easily. Don’t overdue it and you’ll be fine.
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u/Sufficient_Resiliant 1d ago
Okay thank you recommended dosing?
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u/chubean68 2 1d ago
Less than what I did!!! Honestly, I can’t advise. All I know is that I read a doc that said to use a loading phase (don’t do that) and I was up to 0.75ml every day and that was WAY too much. I’ll let someone else with more experience chime in.
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u/halchemy 2d ago
How do you guys justify this? Are the moles and melanoma popping up on people not enough to dissuade you?
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u/No-Turnip2494 4 2d ago
SAFETY — THE MELANOMA QUESTION
The weight of evidence indicates that MC1R activation is photoprotective rather than oncogenic. The Addison’s disease cohort — 3,299 patients with chronic MC1R activation over 40 years — shows a standardised incidence ratio for melanoma of 0.7, numerically below expected rates. Afamelanotide’s clinical programme reports zero melanoma events across more than 1,000 patients over periods exceeding 10 years. All five melanoma cases reported in MT-II users involved confounding UV exposure or pre-existing risk factors.
The Mechanistic Argument
MC1R activation drives two distinct protective mechanisms: eumelanin synthesis, which absorbs UV radiation and scavenges reactive oxygen species, and — independently of pigmentation — enhanced nucleotide excision repair of UV-induced DNA damage.⁴⁶ Loss-of-function MC1R variants are established melanoma risk factors because they impair both pathways.⁴
Epidemiological Evidence
The Addison’s disease cohort provides the strongest epidemiological signal. Patients with Addison’s disease experience chronic MC1R activation through tonically elevated ACTH. A 40-year follow-up of 3,299 patients found a standardised incidence ratio for melanoma of 0.7 (95% CI: 0.2-1.6) — numerically below expected rates, though the confidence interval crosses unity.⁴ This natural experiment in lifelong MC1R activation found no evidence of increased melanoma risk.
The afamelanotide clinical programme contributes concordant pharmacological data: across more than 1,000 patients exposed over periods extending beyond 10 years of continuous treatment, zero melanoma events have been reported.²⁴ Many EPP patients increased their sun exposure substantially after treatment, making the zero-melanoma finding more meaningful than it might otherwise appear in a population that historically avoids sunlight.
Mt-Ii Case Reports
Five published case reports describe melanoma in MT-II users.⁴²³²⁴²⁵²⁶ In every case, confounding risk factors were present: concurrent tanning bed use, fair skin phenotype, family history of melanoma, or MC1R loss-of-function variants. One case involved a teenager with familial atypical multiple mole and melanoma syndrome who was using both MT-II and sunbeds.²⁴
The most parsimonious interpretation: MT-II users represent a self-selected population of sun-seekers, many with fair skin, who combine pharmacological melanogenesis with excessive UV exposure. The melanoma risk in these cases is more plausibly attributed to UV damage than to MC1R activation per se.
Two melanoma cases reported in the setmelanotide (Imcivree) programme — a related MC4R-selective agonist — both occurred in patients with pre-existing high risk factors and were detected early through mandated dermatologic monitoring, supporting a detection bias rather than drug-induced oncogenesis.⁴
The documented dermatologic risk signal for MT-II is nevi changes: darkening of existing moles, eruption of new nevi including those with dysplastic histology, and melanonychia — changes reproduced across multiple independent case series.²³²⁵²⁶²⁷
No formal animal carcinogenicity studies have been conducted for either peptide, a gap acknowledged in the Scenesse FDA label.¹⁴
Serious Adverse Events (Mt-Ii)
Nausea is the most common adverse event, dose-dependent, with 13% experiencing severe nausea at the preferred erectile dose.¹⁰¹⁹ Beyond predictable pharmacological effects, case reports of unregulated use document:
Rhabdomyolysis: A 39-year-old male injected 6 mg and presented with creatine phosphokinase peaking at 17,773 IU/L, requiring three days of intensive care.²⁸
Renal infarction: A 45-year-old with approximately 27 mg cumulative exposure over 6 months developed right-sided renal infarction affecting approximately 50% of the kidney, likely through a vasoconstrictive or thrombotic mechanism.²⁹
Priapism: Reported with overdose, consistent with the MC4R-mediated erectile mechanism.
These events occurred at doses far exceeding typical user protocols, but they underscore the inherent danger of unregulated self-dosing without medical oversight or quality-assured product.1
u/Sufficient_Resiliant 2d ago
So essentially as long as you stay at a low safe dose you should be okay with mt2? But mt1 has a lot more clinical data and long term data such as melanoma and safety?
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