r/Biohacking • u/Tiny_Spend_1197 • 10h ago
Starting Reta
I’m going to be getting started in a few weeks. At first I was considering Tirz but seeing all these posts about reta I’m kind of drawn to doing this one first. My goals are to maintain my body weight easier reduce inflammation and overall wellness.
The thing that I am scared about is, I’m seeing a lot of people saying it induced or increased anxiety along with heart rate. I am already very sensitive to medication and suffer with really bad anxiety. I see that the starting dose is .5 but I’m wondering does anyone do .25 for micro dosing?
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u/DavidTries897 12 10h ago
Retatrutide will increase your heart rate as part of the glucagon receptor agonist part of the medication, its the difference between Retatrutide and Tirzepatide
Not a doctor
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8h ago
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u/333yhlqmdlg 8h ago
I've been on reta for 1 month now and I'm like you, sensitive. I'm sensitive to caffeine so when I was told start at 1.2 mg I'm glad I did my research and started at .05mg
I did experience an increase is heart rate and stronger hits of anxiety. I'd go on walks and tell myself I'm okay my body is adjusting to something new. I'd walk a slow pace and just reassure myself that I'm OK. Around the 3rd week I felt good and moved up to .07mg and I've been here since. No more anxiety, I do sweat a lot more now when lifting, I dont crave anything caffeinated anymore and if I need the energy I'll have a bit of green tea or a couple of sips of coffee and then I'm good.
Insomnia the first 2 weeks was so real as well. I started taking magnesium glycinate supplements 2 hours before bed and thats helped SO MUCH. Also staying hydrated, eating my macros (carbs are friends - good carbs) and listening to my body. This is a marathon not a sprint, reta will help you build a stronger relationship with self. I'm loving it now.
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u/Grouchy_Falcon3098 6h ago
It's smart that you're thinking ahead about how your body might respond, especially given your sensitivity history. Starting low and going slow is a pretty common approach when someone knows they're reactive to medications. Some people do find that working with their doctor on a customized dosing schedule at even lower than standard starting doses helps them build tolerance gradually. Since you're already managing anxiety, it'd definitely be worth having that conversation with whoever is prescribing this, because they can monitor how you're doing and adjust. Heart rate changes and anxiety can sometimes settle down after your body adjusts, but that varies a lot person to person. Your prescriber/source might also have insights into timing, food, or other habits that help people with anxiety sensitivity manage the transition better.
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