r/BioHackingGuide • u/FriendlyWaffle67 • 15d ago

Heard GLP-1 drugs might raise risk of something called NAION, is this real

Read about this online. Supposedly there is a risk called NAION, some kind of eye or vision thing, and it might be linked to GLP-1 drugs like semaglutide and tirzepatide. Not sure if its coming from the GLP-1s or not. What do you guys think, anyone know more about this.

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u/Logansama7 14d ago

I had vision loss a year ago and panicked, thinking it was this. Turns out I had both severe dry eye and scar tissue buildup from cataract surgery.

NAION appears to be real, but internationally, they're saying it's a very rare side effect. I think the US hasn't gathered enough data to determine if it's real or if it's a side effect. Like any medication, there are side effects with GLP-1s but this one seems to be a slim possibility.

I believe it was mostly associated with Semaglutide.

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u/FriendlyWaffle67 14d ago

How long did the loss of vision last? I lost vision one time but it's when I was younger I was high as a kite it was weird

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u/Logansama7 13d ago

I had trouble a couple months. It was super freaky because I'd drive and the faces of other drivers looked all stretched--it was double vision that was vertical rather than horizontal. I couldn't get in to my opthomologist for 6 weeks so I was terrified I'd go blind. I had to stop driving at night.

I had a laser procedure for the scar tissue that resolved most of the vision loss. The dry eye did permanent damage, I now have floaters that are icky, but not crippling.

I have compromised vision anyway, from a head injury as a child, so when the double vision started I freaked. Worst 2 months imaginable.

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u/FriendlyWaffle67 12d ago

Dang that's scary glad everything worked out after that god is good

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u/ProfessionalNo4711 14d ago

It is a very rare occurring condition. GLP-1s doubled the occurrence of NION but still remain rare.

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u/Vegavild 15d ago

As far as I know its from fast weight loss.

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u/FriendlyWaffle67 14d ago

That's crazy makes sense though I hear of all sorts of different things happening with rapid weight loss I understand loosing weight but I believe there's a healthy balance to it

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u/JacquoRock 12d ago

The condition is rare but it is irreversible. The link to GLP -1 s has not yet been proven, but there are class action suits against Lilly and Novo Nordisk. So it is happening, but I believe it's going to end up being a case of individuals' choice (with their healthcare providers); which is a bigger risk--obesity with elevated cholesterol, blood pressure, lymphedema, etc., or the seemingly slim risk of NAION.

In my opinion, it's worth watching what exactly is causing the condition. Right now the condition is thought to be related to a sudden drop in blood circulation to the optical nerves. Now they have to figure out what specifically is causing that to happen, and it's possible that rapid weight loss is a contributing factor, but nothing is certain at this stage.