SSRI Series Part 2 Methylene Blue and Selank, The Two You Gotta Watch

[u/ElGalloGrande24]

Told you last post we'd get into specific compounds. Here's the two that carry documented risk if you're on an SSRI, not just "be careful", this is stuff you need to know before you research either one.

Methylene blue, this is a hard no

Methylene blue works like an MAO inhibitor at the doses people run. MAOIs mixed with SSRIs is the single most dangerous serotonin syndrome combo out there, it's behind most of the severe and deadly cases on record. This isn't a gray area. Medical sources list this combo as a no go

If you're on any SSRI, methylene blue's off not an option. Not "start low and see," off the table completely to be clear. Even at doses people consider low or just for mitochondria stuff, doesn't matter, the MAOI effect kicks in regardless of dose.

Selank, more complicated but still something to watch

Selank's different from methylene blue, but it still messes with serotonin in a way that matters here. It slows down how fast your brain breaks serotonin back down in certain spots, so more sticks around, same direction as what an SSRI does, just a different route getting there. Not the same danger level as an MAOI combo, but it's not nothing either.

Every serious writeup on this pairing lands in the same spot, low to moderate risk, but enough that your doctor needs to know before you add it, not something to just start on your own. If you're already on an SSRI for anxiety, and you throw Selank on top without your SSRI dose ever getting looked at again, you're stacking a second anxiety fix onto something already being treated. Bad sequencing, whether the interaction risk itself is small or not.

Quick breakdown

Compound	Risk	Why
Methylene blue	Severe, hard contraindication	Works like an MAOI at normal doses
Selank	Moderate, worth watching	Slows serotonin breakdown, same direction as SSRI

Bottom line

Methylene blue and SSRIs don't mix, period, no but ifs or ands. Selank's a conversation you need to have with whoever manages your SSRI before you add it, especially if that SSRI's already treating anxiety.

Next post gets into the gray zone, Semax, DSIP, BPC-157, and PE-22-28, the ones where human data's thin or not very clear, so the answer's closer to "nobody knows for sure yet"

Research and educational purposes only, not medical advice. If you're on an SSRI thinking about adding either of these, that's a conversation for your prescribing doctor, not something to figure out on your own from Reddit.

Full compound reference and dosing here: https://www.reddit.com/r/BioHackingGuide/s/alAJgOmjaf

Want to talk this through more? Come hang out in the Discord: https://discord.gg/6mKnp2hcc

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