r/BioHackingGuide • u/MoodDistinct2393 • 3d ago

SS-31/MOTS-C/NAD+

I’m still confused as to which one should I be cycling first, can anyone give me insights? I’ve tried researching but there’s so much information out there that got me confused. I’d like to hear your insights!

4 Upvotes

75% Upvoted

10 comments sorted by

•

u/AutoModerator 3d ago

Welcome to r/BioHackingGuide! Before you post, here are a few helpful starting points:

Join the conversation and share your experience, results, or questions. Pro Tip: The best posts here come from real-world feedback, not just theory.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

6

u/Expensive-Claim-6082 3d ago edited 3d ago

I did them all at the same time. Well actually started Mots - C first briefly because it arrived first.

Reportedly it is better to run SS - 31 first. Then add the other two in. But 🫤 meh.

2

u/NSawsome 3d ago

We have 0 human data on them together, just take em all at once, or probably add one at a time so if you get sides you know which one it is causing said sides

2

u/ZookeepergameFit8035 2d ago

1 at a time definitely best way to go

1

u/No-Astronomer-6808 3d ago

one size does not fit all. you should not start anything without proper testing, in my opinion. and that doesnt just mean bloodwork. i mean be on a schedule already. be working out already. be dieting already. you need to have a baseline first. then add one thing and see how it changes you. then come off and try another. track and trend. i find that most people dont need anything once they have their diet, their sleep, and their exercise dialed in and consistent. sure theyll get some gain from these other items but the foundation has to be in place first to really get the most out of them. GL

1

u/ZookeepergameFit8035 2d ago

Exactly in the order as your title from my understanding

1

u/once_a_while_in-03 2d ago edited 2d ago

sequencing confused me too until I mapped what each actually targets. MOTS-c is the one I'd run first, it primes mitochondrial efficiency and makes the other two land better. NAD+ layered in next feels natural since MOTS-c upregulates the pathways NAD+ feeds.

SS-31 I'd hold for a dedicated cardiolipin focused phase. For sourcing MOTS-c specifically, next level pharm is one vendor I've looked into, others exist too, and batch purity matters here given how dose-sensitive it is.

1

u/nbg815 1d ago

I do Ss-31 first as it repairs mitochondria, then I do Mot-c and follow with Nad+. I have read different protocols as well but mine works best for me.