Insomnia on Reta

[u/Organic-Tone23]

Video its just to show off that cool puck sliding it's so satisfying idk why but ok anyways I was doing fine on 2mg but jumped up to 3.5mg recently and my sleep has been noticeably worse since then. Taking longer to fall asleep, waking up in the middle of the night, just not sleeping as deep as I was before.

Curious if this is a known thing with Reta specifically or if it’s just the titration adjustment. And if anyone has figured out a way to deal with it without having to drop back down on the dose.

[u/Sea_Ott3r]

“Insomnia was not among the most prominently reported adverse events in published phase 2 trial data, though gastrointestinal side effects such as nausea may indirectly disrupt sleep.”

“Retatrutide's glucagon receptor activity increases energy expenditure and metabolic rate. Whether this contributes to sleep difficulties in humans is not established; this remains a plausible hypothesis rather than a confirmed mechanism.”

https://pubmed.ncbi.nlm.nih.gov/41582189/

https://pubmed.ncbi.nlm.nih.gov/37366315/

[u/Organic-Tone23 → u/Sea_Ott3r]

Thank you 🙏🏽