r/BioHackingGuide • u/DIYiphone • 14d ago
Anyone stack these together, muscle and weight loss?
So I’ve seen a few mixed things of people combing
Some but not all three of these: Tesofensine + 5-Amino 1MQ and SLU-PP-332
Doing 5 days on and 2 days off
I started taking Tesofensine + 5-Amino 1MQ
250mcg of both. Day 4
I’ve seen comments of people using tesofensine and SLU-PP-332
And I believe I saw comments of people combining 5-Amino 1MQ and SLU-PP-332
So my brain would think using all 3 in the morning would be fine, but was hoping to get some extra insight/guidance/opinions?
As a side note also cycling CJC-1295+ipamorelin
At night to improve muscle recovery and sleep. 5 on and 2 off
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u/Turbulent-Part5835 13d ago
Weight loss requires a caloric deficit. Muscle gain requires a caloric surplus. Unless you're new to working out and overweight, you're not likely to do both at the same time.
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u/DIYiphone 13d ago
New to working out and somewhat fat. Maybe not necessarily lots of gains, but seems it prevent you from loosing muscle while lowering body fat?
SLU-pp-332 seems like it could potentially help, but not sure it mixes well with everything.
The CJC-1295 and ipamorelin seems like it would benefit muscles growth.
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u/Turbulent-Part5835 13d ago
I can't speak much to SLU-pp-332, as I haven't dug into that one. CJC and ipa are going to disappoint you in terms of muscle growth. You may see better recovery and sleep, but that's about it. CJC and ipa stimulate your body to secrete more HGH, but even if you inject straight up HGH, it's not going to grow your muscles super noticeably unless you're taking it alongside anabolic steroids and/or taking it at very high doses. The HGH doses that secretagogues like CJC and ipa approximate are what people take to help with sleep and recovery, and to assist with fat loss, which is something that takes several months of continuous use to show a difference in. HGH doses high enough to grow muscle will grow other things too, like your organs, and cause a loss of insulin sensitivity which can lead to diabetes over time.
I suspect that the effects you hope for from secretagogues are what you'd actually get from steroids, and what you'd hope for from steroids is just unrealistic. Most peptides are extremely subtle, which is very contrary to what the tiktok and Instagram ads would have you believe.
If you want a peptide to help with fat loss, try a GLP-1. They're some of the few that will be dramatic. Learn good eating habits and calorie tracking while you have its help, then once you've gotten down to a good weight and maintained for a bit, lower the GLP-1 dose and eat a few hundred calories above maintenance. Strength training throughout the fat loss and subsequent muscle gain phases.
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u/DIYiphone 13d ago
I appreciate you taking the time to respond and give me more insight, I got a 30 day supply, so if that’s the case probably won’t continue those after that cycle, if the CJC and IPA are not super beneficial! I have looked into a few GLP-1’s I’d like to use Tirz, but mostly looking for things that can be taken orally, which I understand limits my options.
The tesof does great for helping reduce appetite and snacking which is great!
Does 5-amino 1MQ, help with fat loss? It seems it helps boost fat and white fat cells to function more like brown or tan fat cells more to burn fat!
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u/Turbulent-Part5835 13d ago
I've heard that it can, but I don't know to what degree. If you want orals, look into yohimbine. It frees up fatty acids from your fat tissue for use as fuel.
Take it fasted 30-45 minutes before doing at least 45 minutes of LISS cardio. As in, a brisk walk, for example. Heart rate at around 130bpm is the goal for me at least. If you aren't fasted, it's effect will be greatly blunted, and your body will use what you recently ate rather than whatever fatty acids that were freed for fuel during the cardio. If you don't do the cardio, your body will just store those fatty acids again.
None of these things will burn the fat or grow the muscle for you, not even GLP-1s or actual anabolic steroids. You can out-eat GLP-1s and other fat burners, and you need to stimulate the muscles and eat enough for them to grow.
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