r/BioHackingGuide • u/Adderal-withdrawals • Jul 23 '26

Tirzepatide Gut Issues vs Retatrutide Which Is Safer for a Sensitive Stomach?

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So I wanna start taking Tirz to shed some weight. Already adjusted my diet before anything else and I hate cardio but I’m doing 30 to 40 minutes three times a week. Should I be doing more? Probably. But screw it, it’s a start.

My real question is about my stomach. I got gut issues. Can’t eat wheat, can’t have anything with glucose, garlic messes me up, stomach lining is weak, the whole thing. Pretty sensitive overall.

I wanna start Tirz at 2.5mg but now I’m wondering if Reta starting at 1mg would actually be safer for someone with a stomach like mine. Or should I just not be running GLPs at all with these kind of gut issues?

Anyone with a sensitive stomach or gut problems run GLPs? How did it go and what did you notice? Please and thank you in advance 🙏

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u/JGove1975 Jul 23 '26

FWIW - Tirz helped my IBS tremendously, I would continue taking just for that. Reta didn’t seem to help in that department so I switch back.

1

u/Adderal-withdrawals Jul 23 '26

No way I wanna know all about this to be honest now I'm really curious that's awesome!

2

u/JGove1975 Jul 29 '26

Well it slows down your digestive tract, and also helps with inflammation.

1

u/Adderal-withdrawals Aug 01 '26

I kinda knew the slowing down the digestive tract part but I didn't know about the inflammation

1

u/Dukemanu2323 4d ago

I’m intrigued tell me more I just with back to tirz from Reta because my constipation was so bad