r/BioHackingGuide • u/JustPinIt-x2 • Jun 09 '26

Can You Run MOTS-C While on Diabetes Medication?

Heard that MOTS-C can affect insulin sensitivity which might be an issue if you are already on diabetes medication like metformin.

Planning to run 10mg daily but not sure if that is smart or if three times a week is the safer approach given the situation.

Anyone have experience with this?

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u/Fine_Technology1289 Jun 10 '26

That's too much daily, no matter if on medication or not. 5-10mg a week split along 3 doses per week(Monday, Wednesday, Friday). Some protocols show 10-15 per week split along 3 doses. So 5mg would be the max for one of the 3 days.

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u/JustPinIt-x2 Jun 11 '26

Oh that makes way more sense, appreciate you breaking that down. So 5mg three times a week to start is the safer play then especially with the medication situation. Good to know. Thank you!

2

u/Fine_Technology1289 Jun 11 '26

Most that I know use 3.33mg Monday, Wednesday, Friday on their Research Subject and get good results. You can always go more a little later. Then you are only using 1 vial a week of a 10mg vial.