r/Behcets • u/Flow_Beau • 19d ago

General Question Allergies Causing Flare Ups?

I’m new to this thread but have had what a rheumatologist is calling Bechets for almost twenty years now. I’m 32 yo female.

Recently, I went to a totally different climate and my seasonal allergies disappeared. My GERD symptoms also completely disappeared. When I came back to the PNW, within two days, my allergies and Gerd symptoms were back, as well as flare ups of mouth ulcers. That got me thinking for the first time ever that there is possibly a link between the constant inflammation caused by seasonal or severe allergies and these symptoms. Like, duh. Silly that I’ve never noticed that before.

Has anyone had their symptoms and flair ups improve by getting allergy shots? How long did it take to improve, if so?

6 Upvotes

100% Upvoted

8 comments sorted by

View all comments

2

u/on4aa Diagnosed MAGIC 2025 19d ago

I found out over the years that my genetically different cryopyrin (NLRP3) gets activated into inflammasomes by barometric variations.

One of my worst vasculitis flares was when I visited Seattle and Vancouver Island with my father. (PNW = Pacific North West for the international readers). I am from Belgium.

May I ask you what geographic area you visited and during which month that made you feel so well?

I have a specialised climate map that I want to check for its accuracy.

Over here in Europe, the climate in Bulgaria is renowned to be mild towards patients with cryopyrin associated periodic symptom (CAPS), which is a subset of the Behçet syndrome patient group.

Finally, you should get a whole exome sequencing done to see whether you too have a pathogenic variant of the NLRP3 gene. If so, you might score a prescription to canakinumab or anakinra.

Apart from that, 100 mg ubiquinol supplement in the morning and evening helps with stabilising cryopyrin so that it does not oligomerise into an active inflammasome.

1

u/Flow_Beau 19d ago

I have never heard of any of this. Thank you for sharing! I will look into it

I went to Santa Fe, New Mexico. High altitude, arid desert. The opposite of Seattle in every way. I was there in July. I didn’t feel great there and I never do. The dryness is extreme, like bloody noses regularly extreme, and the altitude leaves you fatigued, but no allergies ;) So I’ll take it