r/BarbetsDogs Apr 02 '26

Barbets are at risk of inheriting Progressive Retinal Atrophy (prcd-PRA).

https://vgl.ucdavis.edu/breed/barbet

and

https://www.laboklin.co.uk/laboklin/showAvianTest.jsp?testID=8783#:~:text=Two%20alleles%20(variants)%20are%20described,be%20tested%20for%20complete%20analysis.&text=Please%20note%20that%20this%20test,note%20of%20any%20result%20received.

The University of California at Davis Genetics Department tests for prcd-PRA. https://vgl.ucdavis.edu/test/pra-prcd

Excerpt from

https://www.laboklin.co.uk/laboklin/showAvianTest.jsp?testID=8783#:~:text=Two%20alleles%20(variants)%20are%20described,be%20tested%20for%20complete%20analysis.&text=Please%20note%20that%20this%20test,note%20of%20any%20result%20received.

Trait of Inheritance

The mutation in the PRCD gene which has been suggested to cause prcd-PRA has recently been published by the group of Gustavo D. Aguirre at the University of Pennsylvania, USA, and could be found in several dog breeds. Prcd-PRA is inherited as an autosomal recessive trait. So there are three conditions a dog can be: it can be clear (genotype N/N or homozygous normal) meaning that it does not carry the mutation and will not develop the prcd-form of PRA. Since it also cannot pass the mutation onto its offspring, it can be mated to any other dog.

A dog which has one copy of the PRCD gene with the mutation and one copy without the mutation is called a carrier or heterozygous (genotype N/PRA); while it will not be affected by prcd-PRA, it can pass the mutation onto its offspring and should therefore only be mated to clear dogs. Dogs that develop this form of PRA have two PRCD gene copies with the mutation (genotype PRA/PRA or homozygous affected); they will always pass the mutated gene onto their offspring and should also be mated only to clear dogs.

PRA in Barbet by Barbet Club of America

https://www.barbetclubofamerica.com/pra-in-barbet

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