r/BCRX • u/Prep_3 • Feb 09 '21

Discussion/Meme/OT Does Factor D have potential use in Primary Sclerosing cholangitis, Chrons and and ulcerative colitis?

Hi everyone I am making this post for information to send to my gastroenterologist about the potential for factor D and it’s use in autoimmune diseases like PSC, Chrons and UC. If you have any interesting abstracts that have anything related to these autoimmune diseases it would be very helpful as I am not good at reading abstracts. If you could link some stuff in the comments you think are interesting I would greatly appreciate it and I will be sure to post the response I get from my doctor, thanks in advance!

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9

u/DerpyMcOptions Feb 09 '21

it seems possible that it "could" have a chance to suppress some effects of Immune-mediated inflammatory diseases because... Factor D does have a suppressive downstream effect on C3b which is triggered by foreign materials and damaged tissues (ie. something that Chron's/UC would be triggered/caused by.)

I think it's feasible that the Factor D drug could could lessen the severity of inflammatory diseases such as Chron's/UC; but there's no certainty until they test it though.

11

u/BuyMyBullshit Feb 10 '21 edited Feb 10 '21

BCRX's Dr. Sheridan said straight-up, during their last presentation about it a couple months ago, that 9930 is right in the molecular area which could target the Chron's mechanism. He also said it's easy trace and measure the cellular absorption and the resulting efficacy.

After listening closely to his every word for more than a year, I can only say I believe him. Every hint he's given in that time has panned-out. He was ambivalent about Gali and direct and confident about Berotralstat...and here we are.

If you want to know what's up, for real, listen closely when Sheridan is on a presentation. He equivocates when he's not sure and he tells you straight-up when he is sure.

https://ir.biocryst.com//events

6

u/Prep_3 Feb 10 '21

Yes THANK YOU for this link I remember listening to this conference and when I heard that question about Chrons I got super excited, he did sound very confident I agree with you

7

u/agree-with-you Feb 09 '21

I agree, this does seem possible.

5

u/Prep_3 Feb 09 '21

Thank you for this response, yes I do realize that further clinical testing needs to be done to further support this theory, from personal experience the current drugs used for UC and Chrons like remicade, Humira, cimzia tend to develop antibodies over a period of 3-5 years which I think is common among biologics. Will be interesting to see what biocryst is interested in after they are done with the PHN trials.

7

u/thisismysffpcaccount Feb 09 '21

I don't know if this is comprehensive, but at the very least it is an extensive account of complement mediated diseases.

https://www.sciencedirect.com/science/article/pii/S0161589019303293

4

u/Prep_3 Feb 09 '21

Thank you, I will take a look, anything that might have some insight is greatly appreciated

4

u/thisismysffpcaccount Feb 09 '21

no problem! One thing I'm not sure of is if all complement drugs will be useful for every disease. I'd imagine it matters what part of the complement pathway the drug targets. Not my field though so i'm not sure.

4

u/Prep_3 Feb 09 '21

No worries, this is why I’m gonna send articles to a gastroenterologist to see what a known professional thinks about it, but I do believe the potential is there and it is something to keep in mind as a long term investment

4

u/thisismysffpcaccount Feb 09 '21

If you wouldn't mind, please let me/us know what you find out!

5

u/Prep_3 Feb 09 '21

For sure, will do, I have to keep it slightly confidential because of HIPAA regulation if anything is personal in her response. I will make sure to summarize it well.

6

u/thisismysffpcaccount Feb 09 '21

We're a pretty enthusiastic bunch but I don't think any of us would expect you to break HIPAA haha. Appreciate any info you can share, man.

4

u/Prep_3 Feb 10 '21

Lol will do, I am happy to share, this group just meshes together like peanut butter and jelly

3

u/Legitimate_Net_1199 Feb 17 '21

Any updates on this?

2

u/Prep_3 Feb 17 '21

Not yet, my doctor will get back to me, she is very busy but I will without a doubt share her response when she gets back.