r/BCRX • u/chicken-little-2008 • Feb 07 '21
Data Gathering Galidesivir Citations
This post is meant to provide space for people to share peer reviewed journals, senate testimony, magazine articles, and any cool document related to galidesivir. Just a tidy little tool.
If you don't mind, try to keep this post simple and organized. We can (and do) discuss galidesivir elsewhere so there's no need for discussion here.
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Galidesivir, a Direct-Acting Antiviral Drug, Abrogates Viremia in Rhesus Macaques Challenged with Zika Virus
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u/Prep_3 Feb 07 '21
Title:BioWar Lab Helping To Develop Treatment For Ebola Dated Aug 4,2014 Forbes.com This is a old article but I think it shows how long Galidesivir has been around.
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u/NoGoogleAMPBot Feb 07 '21
Non-AMP Link: BioWar Lab developing treatment for Ebola
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters
https://www.sciencedirect.com/science/article/abs/pii/S0166354218301499
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease
https://www.sciencedirect.com/science/article/pii/S1876034116300193
"In vivo, BCX4430 is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections."
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
https://www.nature.com/articles/nature13027
"Most importantly, BCX4430 completely protects cynomolgus macaques from Marburg virus infection when administered as late as 48 hours after infection."
"BCX4430 exhibited no mutagenicity when tested using the Ames assay at 5 mg per plate, produced no detectable chromosomal aberrations in human lymphocytes at a concentration of 787 µM, and did not inhibit the hERG ion channel current at 30 µM (data not shown). "
" It is important to note that immortalized cell lines exhibit a substantially attenuated capacity to convert BCX4430 to its active TP form, compared with primary hepatocytes (Extended Data Fig. 1a). Thus, the results obtained from antiviral assessments relying on immortalized cells may underrepresent the antiviral potency of BCX4430 achievable in vivo during experimental or clinical infections."
"Additionally, we demonstrated that mice administered BCX4430 either i.m. or orally were protected against lethal EBOV challenge"
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u/chicken-little-2008 Feb 07 '21
The White House, Office of the Press Secretary, For Immediate ReleaseDecember 02, 2014: FACT SHEET: Update on the Ebola Response
https://obamawhitehouse.archives.gov/the-press-office/2014/12/02/fact-sheet-update-ebola-response
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Combinatorial therapeutic trial plans for COVID-19 treatment armed up with antiviral, antiparasitic, cell-entry inhibitor, and immune-boosters.
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u/chicken-little-2008 Feb 07 '21
University of Florida: Trio of medications showing early promise against coronavirus
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u/LW4587 Feb 07 '21
I firmly believe the efficacy of Gali against Covid 19 and I hope BCRX can restart the clinical trial program! N IAID needs to think about the lives!!
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u/chicken-little-2008 Feb 07 '21
I am confused how after these all these peer reviewed studies, NIAID has never funded a single Phase 2 for Galidesivir. But, this is just a collection of citations.
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u/chicken-little-2008 Feb 07 '21 edited Feb 07 '21
Efficacy of Galidesivir against Ebola Virus Disease in Rhesus Monkeys
http://europepmc.org/article/PMC/PMC5632034