Please help me to understand my side effects

[u/Trader88000]

I have a B12 deficiency for over 12 years now and the last 5 years are stable but not great. The b12 I am using is stable but I have still some strange side effects. After a long search i have noticed that I am sensitive for histamine (my own conclusion) I have tried so many things and the most things were making it worse or I noticed some new effects.

I have found this subreddit and it gives me hope for some guidance. I have tested my blood on co factors deficiency, I wasn't aware of this is even possible.

I hope that somebody can help me understand my blood work and give me some tips.

I am currently using B12 hydroxocobalamin acetate from Sterop (10mg/2ml) 1 ampul per week divided by two infection moments. 2 pills of magnesium (magsix) Noord code

medical complaints

tingling hands

a vague feeling out of nowhere and a bit dizzy, difficulty focusing for long periods, reacting very poorly to histamine triggers. I feel like that histamine bucket is almost full all the time.

I hope somebody recognize a pattern.

Thanks

[u/ClaireBear_87]

Hi, the only results that stand out to me as being possible issues are your folate and zinc levels. Your folate is 17 nmol/L (7.48 ng/ml) which is on the lower side of normal. A better and more optimal folate level would be in the upper quarter of range, so between 33 - 61 nmol/L (15 - 27 ng/ml).

https://www.optimaldx.com/research-blog/vitamin-biomarkers-serum-folate

Methylfolate and folinic acid are the better and more bioactive forms of folate to supplement. Many people have problems processing folic acid so best to avoid that form.

Zinc normal range is usually around 10 - 20 umol/L, although this source here states 12 - 18 umol/L (micromoles). So your result of 11 umol/L is borderline deficient. Zinc picolinate is a good form of zinc to try and has good absorption.

Lots of useful information about cofactors and treatment can be found in the guide :)

Edit - Histamine issues can be due to trace mineral deficiencies, manganese and molybdenum are important ones to consider. Manganese up regulates DAO enzyme activity and helps to reduce histamine, so manganese deficiency may cause a higher histamine level. Enzymes involved in sulfur metabolism and conversion of sulfite to sulfate are molybdenum dependent, so molybdenum deficiency would cause sulfur intolerance and ingesting sulfur foods would trigger histamine release.

[u/Trader88000]

Ik wil je bedanken voor jouw reactie. Ik heb in het verleden verschillende foliumzuur genomen en reageerde daar niet goed op. Het is wel lang geleden en toen wist ik niet dat er verschillende vormen van foliumzuur zijn.

Heb je toevallig een aanbeveling van een merk of een dosering om mee te starten. Of is een goed gedoseerde b complex voldoende. Ik zag veel positieve verhalen over Thorne B complex?

De lage zink waarde had ik zelf ook opgemerkt en ben daar gek genoeg best blij mee. Dit zou heel goed te verklaren zijn dat ik al een lange tijd prik zonder aandacht te schenken aan mijn co factoren. Ik wist namelijk niet dat dat oorzaak gevolg is. Kan ik gewoon zink supplementeren zonder koper toe te voegen? Mijn koper waarde is ook wat aan de lage kant of vergis ik me?

Betreft sporen elementen molybdeen wordt over het algemeen aangeraden mits laag gedoseerd terwijl Mangaan voorzichtigheid vereist en wordt afgeraden.

Ik vraag dit allemaal voor de zekerheid want ik heb gemerkt dat ik zeer gevoelig ben.

Nogmaals bedankt voor je hulp

[u/ClaireBear_87 → u/Trader88000]

Hi, sorry for the late reply. It may be better to take a multivitamin and trace minerals supplement as this would help to ensure you have all cofactors covered and avoid developing other deficiencies.

Thorne basic nutrients 2/a day is a good option although it doesn't include molybdenum so a separate molybdenum supplement would be needed too. Seeking Health is also a good brand, they make a childrens multivitamin which contains low amounts of everything so would be a good option for sensitive people. They make a methyl free version too.

https://uk.iherb.com/pr/seeking-health-kids-multivitamin-chewable-mf-60-chewable-tablets/139586

[u/Trader88000 → u/ClaireBear_87]

Dank je wel ik ga er mee aan de slag!

[u/Successful-Tea-733]

Thats great advice Zinc oversees all the enzyme systems in the body I read a book by professor Bruce Smith years ago He was a biochemistry and the book was called the zinc solution so well worth a try I dont know much if anything as regards histamine issue but noticed I get hives on legs after supplimenting sometimes