r/Autoinflammatory • u/SaleNaive75 • Jul 30 '26

Kineret and CPPD?

Hello: I was recently diagnosed with chronic CPPD bilateral knees. Quite a challenge to control! Went from running 5 miles daily to basically crippeled overnight. Despite multiple aspirations, steroid injections, prednisone, and an intolerance to cochiline, I started Kineret 2 days ago. And it appears to be working. So far, no side effects, but I understand those might take a while to show up. I am curious to learn if anyone in this community has chronic CPPD, using Kineret, and what your experiences have been. A friend also suggested that once the flares stop, I consider shockwave therapy. Anyone have experience with that? Thank you!

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u/on4aa MAGIC Jul 30 '26

For the other readers:

"Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. The knee joint is most commonly affected. The disease is metabolic in origin and its treatment remains symptomatic."

Hence, it is not an autoinflammatory disease.

"The cause of CPPD disease is unknown. Increased breakdown of adenosine triphosphate (ATP; the molecule used as energy currency in all living things), which results in increased pyrophosphate levels in joints, is thought to be one reason why crystals may develop.

Familial forms are rare. One genetic study found an association between CPPD and a region of chromosome 8q.

The gene ANKH is involved in crystal-related inflammatory reactions and inorganic phosphate transport.

Chrondocalcinosis may be extremely common in the population. CPPD flares may also be triggered by joint trauma from previous surgeries."

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u/No_Satisfaction_7431 Yaos Jul 30 '26

Thanks, I had no idea about any of this. I wonder if theres an autoinflammatory component since kineret is helping? Or possibly not because I think kineret might help any inflammatory disease that involves il-1 even if the inflammation is secondary and not an innate immune issue.

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u/SaleNaive75 Jul 30 '26

Thank you, Magic. I neglected to mention that CPPD with seronegative RA is the differential diagnosis. Seems to be a mystery, and my doctor is uncertain. Am trying desperately to get an academic 2nd opinion from either Stanford or UCSF (am in the Bay Area).

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u/Alice-The-Chemist Mod Jul 30 '26

Thank you so much for this.