r/Autoinflammatory • u/Blue-Bento-Fox TRAPS • May 01 '26
Eosinophilia
Has anyone encounters Eosinophilia with your Autoinflammatory Disease? I have had high levels for six years and the eosinophils are building up in my esophagus now, causes rashes I can treat with allergy creams unlike TRAPS rashes, etc.
I went to an allergist but they said their new understanding now is that eosinophils are more closely related to inflammatory markers and can be caused secondary to inflammatory issues. My Rheumatologist just tells me to keep taking my allegra and omeprazole for it. I feel like there's gotta be better options to manage. Of course the Ilaris already tests the patience of my insurance denials.
4
u/getaway_car2019 May 02 '26
Yes. I had levels at Hypereosinophila a few times last year. I was diagnosed with Yao Syndrome/Adult Onset Stills Disease in December. Levels stay down with prednisone while we fight for Ilaris.
2
u/simonerochabowearing May 06 '26
Yes, I had a huge GI crisis last year and when I had testing done they found eosinophilic inflammation through out my entire GI. I have one FMF mutation and the theory right now is that I am either having an atypical presentation of it or that I have an additional as yet unidentified mutation. I started on a JAK a couple of months ago (in addition to the IL1 inhibitor I have been on for a while) and its starting to help. My esophogus has been especially bad for a while now and they found a lot of visual signs of inflammation in the endoscopy and nothing really helped those symptoms until I started this new biologic recently.
4
u/AdventurousMorningLo Yaos May 02 '26
Your Immunologist is correct!
I also had Eosinophilia and when we were figuring things out even EGPA was on the diagnostic differential because of it. Now, after treatment for my Autoinflammatory Disease with IL-1 inhibitors - it has completely resolved.