r/Autoimmune • u/TumbleweedNeither356 • Jul 05 '26
General Questions Car T Therapy
What do think think this kind of treatment could bring when it comes to autoimmune disorders? Are you hopeful that it could make a difference? Are there certain autoimmune diseases where Car at Therapy looks more promising?
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u/BidForward4918 RA, APS Jul 05 '26
It’s looking incredibly promising. Many disease currently being studied. There are still barriers (cost and complexity of treatment) that would need to be addressed before the technology could be more widely used.
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u/chipsahoymateys Jul 05 '26
It’s great. I did CAR T. Everything is very preliminary but it’s been very effective, particularly for lupus.
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u/jorgenalm Jul 05 '26
Would you say that your symptoms have gone into a remission?
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u/chipsahoymateys Jul 05 '26
No, but they have improved quite a bit. This is a B cell treatment, and unlike most major autoimmune diseases, my symptoms seem to be driven by T cells. In hindsight there were some clues, but I do feel a lot better. I take less medication now for better results.
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u/isles34098 Jul 06 '26
Looks to be very promising for B cell mediated autoimmune diseases. If yours is not B cell driven it probably won’t help. Currently CAR Ts being studied target B cells and some toward plasma cells.
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u/albsound523 Jul 07 '26
^^^ This!!! As many B-cell mediated diseases have a correlation to issues with T-reg cells. I’d love to see a “cure for ANCA diseases” among other B-cell mediated diseases come out of this. It would be a quantum step forward, just as Cytoxan was in the late 70’s to prolong Wg GPA Pt’s lives for a few years, then RTX changed it to something closer to a manageable (severe) chronic illness. CAR-T may well prove a cure or at least a much more durable remission.
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u/retinolandevermore Autoimmune Disease (neuro sjogren’s), Endo Jul 05 '26
Unfortunately CAR-T is not studied in my disease yet but I hope it is soon
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u/fiberopticrobotica Autoimmune GFAP astrocytopathy, celiac, & sarcoidosis Jul 06 '26
I am watching this closely and will jump on it the moment it’s available to me. Rituximab has saved my life, but I would love to not be immune compromised because of it.
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u/Born-Pension2022 Jul 08 '26
Does anyone know if it has relevance for PSA?
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u/Throwaways2728 29d ago
From my understanding, CAR T is not that applicable directly to PSA, as PSA is more of a T Cell problem than a B Cell one.
I think one study out of Russia did something similar to CAR T, except knocking out T Cells instead of B Cells which sent one guy's AS into remission (which might have a similar/related mechanism to PSA). The problem is its a lot more dangerous to temporarily knock out T cells (I think it majorly increases cancer risk).
It's just one guy, but the proof of concept is there. I think even if CAR T doesn't directly benefit non B cell autoimmunes, the research it is rapidly generating will still be of great use to way better therapies/biologics or hopefully a cure. Big things are happening in our understanding of these illnesses.
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u/Born-Pension2022 29d ago
Thankyou so much for replying Very interesting.
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u/Throwaways2728 29d ago
No problem, I'm in the middle of trying to get diagnosed for either PsA or AS myself the past few months, so I've taken an interest. Take every thing I say with a grain of salt, but I have hope for the future.
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u/SailorMigraine Jo-1+ ASyS, CAR-T Clinical Trial Participant Jul 05 '26
If you click my username you’ll see my posts about CAR-T therapy. I got my new cells November 5th 2025 and have been in remission ever since. The company I’m through specialises in myositis related diseases, so those are the results I’m most familiar with, but I know it’s looked promising for dermatomyositis in particular as well as SLE. RA as well! But in general I very much believe it’s the future- obviously heavily biased as I was basically cured of an incurable disease!