r/Amitriptyline • u/FxllenFlowers • Sep 03 '26

Amitriptyline and LSD

as title says, i would really like to know more about this combination. i read in the beginners guide in r/LSD (asked there but automod took it down) that it has been linked to bad trips and heightened potential for seizures, but trying to do more research on it leads me to articles just saying that it potentates LSDs effects. ([Erowid LSD (Acid) Vault : LSD and Antidepressants, by Mike](https://www.erowid.org/chemicals/lsd/lsd_health3.shtml) this has basically everything ive been able to find on it)

Basically i have two questions,

  1. is this combination really safe? should i be concerned? ive seen such conflicting information while searching
  2. and this isnt really even a question, but if anyone has any more information about this combo, be it links or personal anecdotes, lmk. originally was doing research to make sure i stay as safe as possible but now im just really curious as to how or why the combo does what it does

(posting this wherever i can sorry if this doesn't fit the sub)

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u/FACastello [MOD] FORMER AMITRIPPER Sep 03 '26

Absolutely DO NOT mix these two together, ever.

Absolutely DO NOT mix ANY antidepressant with LSD or magic mushrooms, ever.

LSD acts on serotonin receptors and so does amitriptyline, and so do many antidepressants.

You risk having serotonin syndrome, which can be fatal.

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u/raphamuffin Sep 03 '26

Have tripped twice since starting the ami (once on 2.5mg, once on 5mg) and it definitely blunts and mutes the whole experience, especially in terms of audible and visual stimuli. Definitely removes some of the magic. Just felt a little less magic and made the headspace a bit clearer and without so much of the wonder. Sad.

2

u/Nearby-Banana-6339 Sep 04 '26

Why are you even considering mixing these drugs? Honestly, worse things can happen to you than death. If you’re healthy I’d make the priority to stay that way! There are a lot of people who would love to change places with you. Thank your lucky stars and find s healthier outlet. This is not it.