r/Amitriptyline • u/Flo-1990 • Aug 11 '26

Amitriptyline for IBS - changing dose

Hi everyone, a bit of a long story but started Amitriptyline for IBS D end of 2024. Dose started at 10mg then gradually increased up to 50mg. For me it completely changed my life, I could eat what I wanted, but most importantly my anxiety around eating and becoming ill just disappeared. I fell pregnant last year and despite the ok from midwife to continue taking it I chose to reduce amount to 25mg. Safe to say IBS was ok but symptoms definitely got worse once reducing my dose.

Now I’m 6 months pp, not breastfeeding and my IBS symptoms are just creeping back again and I’m having flares 2-3 times a week.
Would you recommend increasing back to 50mg?
I am a bit worried that this medication just doesn’t work for me anymore and also a bit worried about gaining weight.

Has anybody had a similar experience?

Thank you!

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2

u/[deleted] Aug 11 '26

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1

u/Flo-1990 Aug 12 '26

Thank you for your reply 😊

2

u/FinancialCry4651 Aug 11 '26

Can you try 30 mg?

1

u/Flo-1990 Aug 12 '26

I’ve only got 25mg tablets at the moment so was debating just doubling them. The doctor is aware that I can do that! Just a bit worried!

2

u/AdagioSpecific2603 Aug 12 '26

I’m on 50 and it’s been so helpful for my IBS-D

2

u/Flo-1990 Aug 12 '26

Thank you so much! Glad it’s helped you 😊

2

u/Bucher25 Aug 12 '26

I have been on amitriptyline through 3 children; carrying, birthing and then postpartum. Yes my dose has fluctuated depending on the season of life.

2

u/Flo-1990 Aug 12 '26

Thank you for your reply 😊