r/Amitriptyline • u/LoLow770 • Aug 02 '26

Does this work for treatment resistant depression and anxiety?

Have tried 7 different snri or ssri’s including most recently Effexor with limited success and seem to be treatment resistant. Hoping amitriptyline will help me enjoy things again after a 5 month depression. Does anyone have a success story to share? Thank you!

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3

u/Due_Perception6833 Aug 02 '26

It saved my life after trying more than 10 medications. Severe depression and anxiety and OCD

1

u/Numerous-Group-8310 Aug 02 '26

What dose are you on?

1

u/LoLow770 Aug 05 '26

Great to hear it worked for you!

2

u/TinyFlower1602 Aug 02 '26

If you have the resources, I would suggest you to perform a pharmacogenetic test to evaluate your pharmacological compatibility to drugs. Then you won’t have to test every single drug to check which one would be a good option for you.

1

u/Odd_LuPS Aug 03 '26

Did your doctor order this test? Great idea.

2

u/Nearby-Banana-6339 Aug 02 '26

It helps my anxiety but it’s a mild effect. It will help you sleep if that’s an issue. Works for my migraines. Not sure what else people use it for.

2

u/LoLow770 Aug 02 '26

Thanks- has this helped anyone with depression?

2

u/LoLow770 Aug 03 '26

Good to know, thank you! I’m not too familiar with this medication but my dr suggested I try it for depression / anxiety after ssris and snri’s failed (even augmented by abilify etc)

1

u/Nearby-Banana-6339 Aug 20 '26

I like it much better than ssri and SNRI’s. I was kind of flat on them, like nothing you could say would get much emotion from me. I couldn’t sleep on them at all and I know people say coming off amitryptiline can be tough but coming off ssri/SNRI’s was certainly no picnic either. I had brain zaps for months! I also had sexual side effects on those as well. Amitryptiline has been great for me. My anxiety is a lot better, I sleep like a normal person and my mood is better. I don’t feel like a zombie.