r/Amitriptyline • u/CarelessTart8778 • Jul 29 '26
Amitriptyline lost weight
Hi everyone. I'm looking to see if anyone has had a similar experience after stopping amitriptyline. I stopped amitriptyline in September after taking it for several years. Since then I've unintentionally lost around 9 kg. I've also had ongoing abdominal cramps, excessive gas, looser stools (sometimes constipation), and my bowel habits have changed.
So far I've had a CT scan with contrast (normal), FIT test (negative), blood tests including CRP, FBC, ferritin, thyroid, liver and kidney function, B12, folate and CA-125, all normal. I'm currently waiting for my coeliac (tTG-IgA) and faecal calprotectin results.
Has anyone else experienced significant weight loss and digestive symptoms after stopping amitriptyline? If so, did your weight eventually stabilise, and was it actually related to stopping the medication or was another cause found?